Publication Name	World Journal of Gastroenterology
Manuscript ID	36404
Country	Japan

Received	2017-10-05 16:59
Peer-Review Started	2017-10-06 09:35
To Make the First Decision	2017-10-18 06:48
Return for Revision	2017-10-19 09:00
Revised	2017-10-30 04:30
Second Decision	2017-11-14 06:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-14 18:53
Articles in Press	2017-11-14 18:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-04 11:29
Publish the Manuscript Online	2017-12-12 08:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Early gastric cancer frequently has high expression of KK-LC-1, a cancer-testis antigen
Manuscript Source	Unsolicited Manuscript
All Author List	Nobue Futawatari, Takashi Fukuyama, Rui Yamamura, Akiko Shida, Yoshihito Takahashi, Yatsushi Nishi, Yoshinobu Ichiki, Hitoshi Yamazaki, Noritada Kobayashi and Masahiko Watanabe
ORCID	Author(s) ORCID Number Nobue Futawatari http://orcid.org/0000-0001-5666-308X Takashi Fukuyama http://orcid.org/0000-0003-1772-3478 Rui Yamamura http://orcid.org/0000-0003-3891-1929 Akiko Shida http://orcid.org/0000-0002-7457-5160 Yoshihito Takahashi http://orcid.org/0000-0001-9433-0403 Yatsushi Nishi http://orcid.org/0000-0002-6605-092X Yoshinobu Ichiki http://orcid.org/0000-0002-1293-6952 Hitoshi Yamazaki http://orcid.org/0000-0001-9452-1445 Noritada Kobayashi http://orcid.org/0000-0003-0321-6379 Masahiko Watanabe http://orcid.org/0000-0001-5801-7559
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI 26670609 JSPS KAKENHI 21700510 JSPS KAKENHI 17K16578 Takeda Science Foundation a Kitasato University Research Grant for Young Researchers Grant-in-Aid for research by Kitasto University Medical Center H25-10
Corresponding Author	Takashi Fukuyama, PhD, Academic Research, Research Scientist, Division of Biomedical Research, Kitasato University Medical Center, Arai 6-100, Kitamoto 364-8501, Japan. fukuyam@insti.kitasato-u.ac.jp
Key Words	Gastric cancer; Cancer-testis antigen; Kitakyushu lung cancer antigen-1; Melanoma antigen-A1; Melanoma antigen-A3; New York esophageal cancer-1; Clinicopathological factor; Early stage
Core Tip	The Kitakyushu lung cancer antigen-1 (KK-LC-1) is a relatively later cancer-testis antigen and has received interest because it was reported that KK-LC-1 is a predominant antigen for cancer immunotherapy. We found that the expression rate of KK-LC-1 in gastric cancer was 79.5%, which was higher than that of other cancer-testis antigens and the same as that in both early- and late-stage patients. KK-LC-1 is a potential biomarker for early detection of gastric cancer and identification of patients at high risk for gastric cancer. Furthermore, KK-LC-1 is a potential target for immunotherapy in gastric cancer.
Publish Date	2017-12-12 08:34
Citation	Futawatari N, Fukuyama T, Yamamura R, Shida A, Takahashi Y, Nishi Y, Ichiki Y, Kobayashi N, Yamazaki H, Watanabe M. Early gastric cancer frequently has high expression of KK-LC-1, a cancer-testis antigen. World J Gastroenterol 2017; 23(46): 8200-8206
URL	http://www.wjgnet.com/1007-9327/full/v23/i46/8200.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i46.8200

Full Article (PDF)	WJG-23-8200.pdf
Full Article (Word)	WJG-23-8200.doc
Manuscript File	36404-Review.docx
Answering Reviewers	36404-Answering reviewers.pdf
Audio Core Tip	36404-Audio core tip.wav
Biostatistics Review Certificate	36404-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36404-Conflict-of-interest statement.pdf
Copyright License Agreement	36404-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	36404-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	36404-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	36404-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36404-Language certificate.pdf
Peer-review Report	36404-Peer-review(s).pdf
Scientific Misconduct Check	36404-Scientific misconduct check.pdf
Scientific Editor Work List	36404-Scientific editor work list.pdf