Publication Name	World Journal of Gastroenterology
Manuscript ID	36449
Country	Japan

Received	2017-10-31 11:25
Peer-Review Started	2017-11-01 01:31
First Decision by Editorial Office Director	2017-11-14 05:37
Return for Revision	2017-11-16 09:39
Revised	2017-11-21 10:37
Publication Fee Transferred
Second Decision by Editor	2017-11-27 10:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-11-27 20:04
Articles in Press	2017-11-27 20:04
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-19 03:47
Publish the Manuscript Online	2017-12-27 11:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott–Aldrich syndrome protein gene
Manuscript Source	Unsolicited Manuscript
All Author List	Takashi Ohya, Masakatsu Yanagimachi, Kentaro Iwasawa, Shuichiro Umetsu, Tsuyoshi Sogo, Ayano Inui, Tomoo Fujisawa and Shuichi Ito
ORCID	Author(s) ORCID Number Takashi Ohya http://orcid.org/0000-0002-0898-0539 Masakatsu Yanagimachi http://orcid.org/0000-0003-0153-7283 Kentaro Iwasawa http://orcid.org/0000-0002-5387-0099 Shuichiro Umetsu http://orcid.org/0000-0002-6129-5127 Tsuyoshi Sogo http://orcid.org/0000-0001-8986-1699 Ayano Inui http://orcid.org/0000-0002-1973-4376 Tomoo Fujisawa http://orcid.org/0000-0002-5046-0318 Shuichi Ito http://orcid.org/0000-0002-5242-8987
Funding Agency and Grant Number
Corresponding Author	Masakatsu Yanagimachi, MD, PhD, Assistant Professor, Department of Pediatrics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113-8519, Tokyo, Japan. myanagimachi.ped@tmd.ac.jp
Key Words	Inflammatory bowel disease; Wiskott–Aldrich syndrome; Primary immunodeficiency; Children; Screening
Core Tip	Inflammatory bowel disease (IBD) has multiple etiologies, including genetic and environmental factors. Recent reports have described how some children with Wiskott–Aldrich syndrome (WAS) present IBD or IBD-like gastroenterocolitis. In this study, we found a WAS c.1378C>T, p.Pro460Ser mutation in three children with IBD. These patients did not present typical symptoms of WAS, such as thrombocytopenia and recurrent infection. However, WAS is known to be associated with an increased risk of malignancies including lymphoma, as well as autoimmune diseases. Therefore, in any long-term follow-up, the analysis of WASP expression in children with IBD should be considered even if major symptoms of WAS are absent.
Publish Date	2017-12-27 11:08
Citation	Ohya T, Yanagimachi M, Iwasawa K, Umetsu S, Sogo T, Inui A, Fujisawa T, Ito S. Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene. World J Gastroenterol 2017; 23(48): 8544-8552
URL	http://www.wjgnet.com/1007-9327/full/v23/i48/8544.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i48.8544

Full Article (PDF)	WJG-23-8544.pdf
Full Article (Word)	WJG-23-8544.doc