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Articles Published Processes
12/27/2017 11:08:07 AM | Browse: 1224 | Download: 1235
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Received |
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2017-10-31 11:25 |
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Peer-Review Started |
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2017-11-01 01:31 |
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To Make the First Decision |
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2017-11-14 07:10 |
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Return for Revision |
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2017-11-16 09:39 |
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Revised |
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2017-11-21 10:37 |
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Second Decision |
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2017-11-27 10:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-11-27 20:04 |
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Articles in Press |
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2017-11-27 20:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-12-19 03:47 |
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Publish the Manuscript Online |
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2017-12-27 11:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott–Aldrich syndrome protein gene
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takashi Ohya, Masakatsu Yanagimachi, Kentaro Iwasawa, Shuichiro Umetsu, Tsuyoshi Sogo, Ayano Inui, Tomoo Fujisawa and Shuichi Ito |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Masakatsu Yanagimachi, MD, PhD, Assistant Professor, Department of Pediatrics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113-8519, Tokyo, Japan. myanagimachi.ped@tmd.ac.jp |
| Key Words |
Inflammatory bowel disease; Wiskott–Aldrich syndrome; Primary immunodeficiency; Children; Screening |
| Core Tip |
Inflammatory bowel disease (IBD) has multiple etiologies, including genetic and environmental factors. Recent reports have described how some children with Wiskott–Aldrich syndrome (WAS) present IBD or IBD-like gastroenterocolitis. In this study, we found a WAS c.1378C>T, p.Pro460Ser mutation in three children with IBD. These patients did not present typical symptoms of WAS, such as thrombocytopenia and recurrent infection. However, WAS is known to be associated with an increased risk of malignancies including lymphoma, as well as autoimmune diseases. Therefore, in any long-term follow-up, the analysis of WASP expression in children with IBD should be considered even if major symptoms of WAS are absent. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Ohya T, Yanagimachi M, Iwasawa K, Umetsu S, Sogo T, Inui A, Fujisawa T, Ito S. Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene. World J Gastroenterol 2017; 23(48): 8544-8552 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8544.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8544 |
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