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Articles Published Processes
1/26/2018 8:09:36 AM | Browse: 889 | Download: 1190
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Received |
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2017-10-06 12:57 |
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Peer-Review Started |
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2017-10-07 14:25 |
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To Make the First Decision |
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2017-11-23 02:20 |
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Return for Revision |
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2017-11-24 02:38 |
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Revised |
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2017-11-28 07:44 |
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Second Decision |
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2017-12-14 10:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-12-29 01:13 |
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Articles in Press |
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2017-12-29 01:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-20 08:51 |
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Publish the Manuscript Online |
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2018-01-26 08:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bioengineered humanized livers as better three-dimensional drug testing model system
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sandeep Kumar Vishwakarma, Avinash Bardia, Chandrakala Lakkireddy, Raju Nagarapu, Md Aejaz Habeeb and Aleem Ahmed Khan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aleem Ahmed Khan, PhD, Associate Professor, Research Scientist, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com |
| Key Words |
Acellularization; Repopulation; Drug testing; Humanized liver; Bioengineering |
| Core Tip |
Liver is the central organ for absorption, distribution, metabolism, excretion and toxicity (ADMET) of pharmacological drugs and molecules. Available in vitro and in vivo preclinical models deals with several limitations including xenogeneic barrier, lack of natural humanized liver architecture and functional responses. Bioengineered humanized livers developed in present study can overcome on such limitations. This humanized liver model system provides better platform which could be used more efficiently to screen the ADMET of several pipeline drugs and other pharmacological molecules. This approach could reduce the time and cost of the total drug screening experiments as compared to the animal models. It provides enhanced dose response relationship by using drug concentrations relative to human exposure. Ease of ex-vivo access of cellular and molecular responses in humanized liver model system during pharmacological screening also offers high-throughput studies to determine the cellular response networks and toxicity pathways. |
| Publish Date |
2018-01-26 08:09 |
| Citation |
Vishwakarma SK, Bardia A, Lakkireddy C, Nagarapu R, Habeeb MA, Khan AA. Bioengineered humanized livers as better three-dimensional drug testing model system. World J Hepatol 2018; 10(1): 22-33 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i1/22.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i1.22 |
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