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Articles Published Processes
2/27/2018 5:35:20 AM | Browse: 934 | Download: 1235
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Received |
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2017-10-23 03:13 |
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Peer-Review Started |
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2017-10-23 20:38 |
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To Make the First Decision |
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2017-11-08 03:16 |
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Return for Revision |
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2017-11-09 00:54 |
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Revised |
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2017-11-14 15:54 |
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Second Decision |
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2017-11-27 09:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-27 20:13 |
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Articles in Press |
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2017-11-27 20:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-02-21 04:26 |
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Publish the Manuscript Online |
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2018-02-27 05:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Relaxin influences ileal muscular activity through a dual signaling pathway in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Eglantina Idrizaj, Rachele Garella, Fabio Francini, Roberta Squecco and Maria Caterina Baccari |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Florence |
ROBERTASQUECCORICATEN15 (to Squecco R) |
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| Corresponding Author |
Roberta Squecco, PhD, Research Scientist, Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Viale Morgagni 63, Florence 50134, Italy. roberta.squecco@unifi.it |
| Key Words |
Relaxin; Gastrointestinal motility; Smooth muscle; AC/cAMP; GC/cGMP |
| Core Tip |
Up to now relaxin (RLX) was described to act only through the NO/ guanylate cyclase (GC)/cGMP/PKG pathway in different gastrointestinal tracts. The results of the present study, achieved on mice ileal preparations and carried out by a combined mechanical and electrophysiological approach, demonstrate for the first time that both GC and adenylate cyclase are involved in the effects of RLX in this intestinal region. The activation of this dual signaling pathway by RLX might represent a reinforcing (redundant) myorelaxant mechanism in the ileum, underlying the physiological importance of the hormone and leading to speculate translational perspectives in the treatment of intestinal dysmotilities. |
| Publish Date |
2018-02-27 05:35 |
| Citation |
Idrizaj E, Garella R, Francini F, Squecco R, Baccari MC. Relaxin influences ileal muscular activity through a dual signaling pathway in mice. World J Gastroenterol 2018; 24(8): 882-893 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i8/882.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i8.882 |
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