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1/12/2018 9:26:11 AM | Browse: 359 | Download: 203
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 36858
Country/Territory United States
2017-10-28 07:12
Peer-Review Started
2017-10-29 04:12
To Make the First Decision
2017-11-23 02:23
Return for Revision
2017-11-24 03:07
2017-11-29 16:20
Second Decision
2017-12-01 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-12-07 01:08
Articles in Press
2017-12-07 01:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-01-08 17:10
Publish the Manuscript Online
2018-01-12 09:26
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer
Manuscript Source Invited Manuscript
All Author List Minoru Koi, Stephanie S Tseng-Rogenski and John M Carethers
Author(s) ORCID Number
Minoru Koi http://orcid.org/0000-0002-1195-071X
Stephanie S Tseng-Rogenski http://orcid.org/0000-0001-5195-3176
John M Carethers http://orcid.org/0000-0003-2623-7332
Funding Agency and Grant Number
Funding Agency Grant Number
United States Public Health Service DK067287
United States Public Health Service CA162147
United States Public Health Service CA206010
A. Alfred Taubman Medical Research Institute of the University of Michigan
Corresponding author John M Carethers, BSc, MD, Full Professor, Professor and Chair, Division of Gastroenterology, Department of Internal Medicine, and Comprehensive Cancer Center, University of Michigan, 3101 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI48109-5368, United States. jcarethe@umich.edu
Keywords Microsatellite instability; Microsatellite stable; Elevated microsatellite alterations at selected tetranucleotide repeats; Colorectal cancer; Mismatch repair; Inflammation; MSH3
Core Tip Inflammation can trigger microsatellite stable colorectal cancers (CRCs) to acquire a nuclear-to-cytoplasm displacement of the DNA mismatch repair protein MSH3, rendering the CRC with di- and tetranucleotide microsatellite instability (MSI-low/elevated microsatellite alterations at selected tetranucleotide repeats) and modifying the biological behavior of the CRC towards metastasis and poor patient survival. We herein discuss the mechanisms and significance of these induced inflammatory-associated microsatellite alterations, and suggest three content areas to further examine interventions that may modify the observed behavior of these CRCs.
Publish Date 2018-01-12 09:26
Citation Koi M, Tseng-Rogenski SS, Carethers JM. Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer. World J Gastrointest Oncol 2018; 10(1): 1-14
Url http://www.wjgnet.com/1948-5204/full/v10/i1/1.htm
DOI http://dx.doi.org/10.4251/wjgo.v10.i1.1
Full Article (PDF) WJGO-10-1.pdf
Full Article (Word) WJGO-10-1.doc
Manuscript File 36858-Review.docx
Answering Reviewers 36858-Answering reviewers.pdf
Audio Core Tip 36858-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 36858-Conflict-of-interest statement.pdf
Copyright License Agreement 36858-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 36858-Grant application form(s).pdf
Peer-review Report 36858-Peer-review(s).pdf
Scientific Misconduct Check 36858-Scientific misconduct check.pdf
Scientific Editor Work List 36858-Scientific editor work list.pdf