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Articles Published Processes
1/12/2018 9:26:11 AM | Browse: 905 | Download: 1012
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Received |
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2017-10-28 07:12 |
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Peer-Review Started |
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2017-10-29 04:12 |
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To Make the First Decision |
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2017-11-23 02:23 |
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Return for Revision |
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2017-11-24 03:07 |
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Revised |
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2017-11-29 16:20 |
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Second Decision |
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2017-12-01 08:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2017-12-07 01:08 |
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Articles in Press |
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2017-12-07 01:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-08 17:10 |
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Publish the Manuscript Online |
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2018-01-12 09:26 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Minoru Koi, Stephanie S Tseng-Rogenski and John M Carethers |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| United States Public Health Service |
DK067287 |
| United States Public Health Service |
CA162147 |
| United States Public Health Service |
CA206010 |
| A. Alfred Taubman Medical Research Institute of the University of Michigan |
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| Corresponding Author |
John M Carethers, BSc, MD, Full Professor, Division of Gastroenterology, Department of Internal Medicine, and Comprehensive Cancer Center, University of Michigan, 3101 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5368, United States. jcarethe@umich.edu |
| Key Words |
Microsatellite instability; Microsatellite stable; Elevated microsatellite alterations at selected tetranucleotide repeats; Colorectal cancer; Mismatch repair; Inflammation; MSH3 |
| Core Tip |
Inflammation can trigger microsatellite stable colorectal cancers (CRCs) to acquire a nuclear-to-cytoplasm displacement of the DNA mismatch repair protein MSH3, rendering the CRC with di- and tetranucleotide microsatellite instability (MSI-low/elevated microsatellite alterations at selected tetranucleotide repeats) and modifying the biological behavior of the CRC towards metastasis and poor patient survival. We herein discuss the mechanisms and significance of these induced inflammatory-associated microsatellite alterations, and suggest three content areas to further examine interventions that may modify the observed behavior of these CRCs. |
| Publish Date |
2018-01-12 09:26 |
| Citation |
Koi M, Tseng-Rogenski SS, Carethers JM. Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer. World J Gastrointest Oncol 2018; 10(1): 1-14 |
| URL |
http://www.wjgnet.com/1948-5204/full/v10/i1/1.htm |
| DOI |
http://dx.doi.org/10.4251/wjgo.v10.i1.1 |
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