Publication Name	World Journal of Nephrology
Manuscript ID	3700
Country

Received	2013-05-16 08:23
Peer-Review Started	2013-05-16 14:53
To Make the First Decision	2013-05-23 17:20
Return for Revision	2013-05-24 14:44
Revised	2013-06-11 00:26
Second Decision	2013-10-18 09:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-18 10:05
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-01 16:00
Publish the Manuscript Online	2013-11-04 12:41

ISSN	2220-6124 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Vitamin E and diabetic nephropathy in mice model and humans
Manuscript Source
All Author List	Nakhoul Farid, Dahan Inbal, Nakhoul Nakhoul, Farber Evgeny, Rachel Miller-Lotan, Andrew P Levy and Asleh Rabea
Funding Agency and Grant Number
Corresponding Author	Nakhoul Farid, MD, Department of Nephrology and Hypertension, Baruch-Padeh Poriya Medical Center, Faculty of Medicine, Bar Ilan University Galilee, Max ve-Anna Webb, Ramat Gan, Lower Galilee 15208, Israel. fnakhoul@poria.health.gov.il
Key Words	Haptoglobin; Cardio-vascular complications; Diabetic nephropathy; Vitamin E
Core Tip	In diabetes mellitus there is an increase in oxygen radical formation due to glucose auto oxidation, the formation of advanced glycosylation end products, and metabolic stress. Epidemiologic studies suggest that vitamin E supplementation might decrease the risk of developing cardiovascular disease, others showed increased risk of cardiac death with the vitamin E treatment. To the contradictory results in the literature regarding the beneficial role of vitamin E in protecting against cardiovascular complications, high dose vitamin E supplementation has not been recommended by the medical community. In fact, a meta-analysis of over 135000 individuals treated with vitamin E concluded that high dose vitamin E (greater than 400 mg/d) slightly increases the risk of mortality. However, recent investigations into the polymorphic serum protein haptoglobin (Hp) indicate that vitamin E may be beneficial in a genetically defined subgroup of patients, namely, diabetic patients of the Hp 2-2 genotype. The role of Hp as an antioxidant, its importance in diabetes, and the therapeutic role of vitamin E will be discussed in this review.
Publish Date	2013-11-04 12:41
Citation	Farid N, Inbal D, Nakhoul N, Evgeny F, Miller-Lotan R, Levy AP, Rabea A. Vitamin E and diabetic nephropathy in mice model and humans. World J Nephrol 2013; 2(4): 111-124
URL	http://www.wjgnet.com/2220-6124/full/v2/i4/111.htm
DOI	http://dx.doi.org/10.5527/wjn.v2.i4.111

Full Article (PDF)	WJN-2-111.pdf
Manuscript File	3700-Review.docx
Answering Reviewers	3700-Answering reviewers.pdf
Copyright License Agreement	3700-Copyright assignment.pdf
Peer-review Report	3700-Peer review.pdf
Scientific Editor Work List	3700-Scientific editor work list.doc