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Articles Published Processes
1/26/2018 8:09:36 AM | Browse: 1309 | Download: 1701
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Received |
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2017-11-09 14:31 |
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Peer-Review Started |
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2017-11-10 06:37 |
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To Make the First Decision |
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2017-12-01 07:23 |
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Return for Revision |
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2017-12-04 03:30 |
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Revised |
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2017-12-21 09:13 |
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Second Decision |
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2018-01-12 08:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-15 22:24 |
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Articles in Press |
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2018-01-15 22:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-01-25 03:14 |
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Publish the Manuscript Online |
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2018-01-26 08:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of inflammatory response in liver diseases: Therapeutic strategies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jose A Del Campo, Paloma Gallego and Lourdes Grande |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Insituto de Salud Carlos III |
PI14/01349 |
| Consejería de Salud, Junta de Andalucía |
PI0892-2012 |
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| Corresponding Author |
Jose A Del Campo, PhD, Senior Scientist, Department of Digestive Diseases, Valme University Hospital, Avda. Bellvista s/n, Sevilla 41014, Spain. jantonio.delcampo@ciberehd.org |
| Key Words |
Caspase-1; Fibrosis; Hepatitis C virus; Inflammasome; Interleukin-1α; Interleukin-1β; Liver disease; Non-alcoholic fatty liver disease; NLRP3; Tumor necrosis factor-alpha |
| Core Tip |
Inflammasomes are newly recognized vital players in innate immunity. Several factors have been identified able to activate the NLRP3 inflammasome. Inappropriate activation of NLRP3 can contribute to the onset and progression of various diseases, particularly age-related diseases. It is well established that hepatitis C virus infection plays a critical role in the promotion of liver inflammation and disease, inducing the production of IL-1β and the activation of NLRP3. NLRP3 inflammasome gain of function aggravates liver disease, resulting in severe liver fibrosis and lately, hepatocellular carcinoma. In non-alcoholic fatty liver disease, the regulation of inflammation processes may prevent the progression of non-alcoholic steatohepatitis to fibrosis. |
| Publish Date |
2018-01-26 08:09 |
| Citation |
Del Campo JA, Gallego P, Grande L. Role of inflammatory response in liver diseases: Therapeutic strategies. World J Hepatol 2018; 10(1): 1-7 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i1/1.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i1.1 |
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