Publication Name	World Journal of Gastroenterology
Manuscript ID	37130
Country	China

Received	2017-11-15 17:09
Peer-Review Started	2017-11-16 08:14
To Make the First Decision	2017-12-20 07:33
Return for Revision	2017-12-21 10:47
Revised	2017-12-26 16:14
Second Decision	2018-01-15 08:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-15 20:36
Articles in Press	2018-01-15 20:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-20 11:34
Typeset the Manuscript	2018-03-03 12:31
Publish the Manuscript Online	2018-03-05 11:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Mu-Lin Liu, Qiao Zhang, Xiao Yuan, Long Jin, Li-Li Wang, Tao-Tao Fang and Wen-Bin Wang
ORCID	Author(s) ORCID Number Mu-Lin Liu http://orcid.org/0000-0003-3930-678X Qiao Zhang http://orcid.org/0000-0001-5413-4547 Xiao Yuan http://orcid.org/0000-0002-4299-7377 Long Jin http://orcid.org/0000-0002-7765-4091 Li-Li Wang http://orcid.org/0000-0003-0439-8119 Tao-Tao Fang http://orcid.org/0000-0002-1831-1937 Wen-Bin Wang http://orcid.org/0000-0002-9023-6855
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Foundation of Anhui Education Department KJ2017A219 Scientific Research Foundation of Academic Leader of Anhui Province 2016H105 Education Talent Foundation of Universities of Anhui Education Department gxbjZD2016070 National Natural Science Foundation of China 81500373 Natural Science Foundation of Anhui Province 1608085MH193
Corresponding Author	Wen-Bin Wang, PhD, Doctor, Professor, Department of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, No. 372, Tunxi Road, Hefei 230022, Anhui Province, China. surdoctor@163.com
Key Words	Colorectal cancer; long noncoding RNA RP4; SH3GLB1; miR-7-5p; competing endogenous RNA
Core Tip	In the present study, we investigated the role of long noncoding RNA (lncRNA) RP4 in colorectal cancer using an in vivo cell model and an in vivo xenograft model. Mechanistic analysis suggested that lncRNA RP4 functions in colorectal cancer pathogenesis as a competing endogenous RNA that regulates SH3GLB1 expression by acting as a sponge for miR-7-5p. It could also serve as a potential therapeutic target for colorectal cancer treatment.
Publish Date	2018-03-05 11:23
Citation	Liu ML, Zhang Q, Yuan X, Jin L, Wang LL, Fang TT, Wang WB. Long noncoding RNA RP4 functions as a competing endogenous RNA through miR-7-5p sponge activity in colorectal cancer. World J Gastroenterol 2018; 24(9): 1004-1012
URL	http://www.wjgnet.com/1007-9327/full/v24/i9/1004.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i9.1004

Full Article (PDF)	WJG-24-1004.pdf
Full Article (Word)	WJG-24-1004.doc
Manuscript File	37130-Review.docx
Answering Reviewers	37130-Answering reviewers.pdf
Audio Core Tip	37130-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37130-Conflict-of-interest statement.pdf
Copyright License Agreement	37130-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37130-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	37130-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	37130-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	37130-Language certificate.pdf
Peer-review Report	37130-Peer-review(s).pdf
Scientific Misconduct Check	37130-Scientific misconduct check.pdf
Scientific Editor Work List	37130-Scientific editor work list.pdf