Publication Name	World Journal of Meta-Analysis
Manuscript ID	37300
Country	Romania

Received	2017-12-04 01:09
Peer-Review Started	2017-12-04 02:19
To Make the First Decision	2017-12-26 00:27
Return for Revision	2017-12-27 02:41
Revised	2018-01-17 17:24
Second Decision	2018-02-01 09:10
Accepted by Journal Editor-in-Chief	2018-02-02 14:27
Accepted by Company Editor-in-Chief	2018-03-01 18:41
Articles in Press	2018-03-01 18:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-06 06:42
Publish the Manuscript Online	2018-03-07 08:05

ISSN	2308-3840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Systematic Reviews
Article Title	Genetic studies in irritable bowel syndrome-status quo
Manuscript Source	Invited Manuscript
All Author List	Stefan-Lucian Popa, Dan L Dumitrascu, Romana Vulturar and Beate Niesler
ORCID	Author(s) ORCID Number Stefan-Lucian Popa http://orcid.org/0000-0002-5508-2598 Dan L Dumitrascu http://orcid.org/0000-0001-5404-7662 Romana Vulturar http://orcid.org/0000-0003-2476-9706 Beate Niesler http://orcid.org/0000-0001-7881-6112
Funding Agency and Grant Number
Corresponding Author	Dan L Dumitrascu, PhD, Full Professor, Department of 2nd Medical, “Iuliu Hatieganu” University of Medicine and Pharmacy, Clinicilor Street nr3-5, Cluj-Napoca 400006, Romania. dan_dumitrascu@yahoo.de
Key Words	Irritable bowel syndrome; Genetic polymorphisms; Gene
Core Tip	The main genetic polymorphisms encountered in irritable bowel syndrome (IBS) are: Serotonin transporter (SERT) gene (SLC6A4), guanine nucleotide-binding protein subunit beta-3 (GNbeta3), serotonin type 3 receptor genes (HTR3A), (HTR3E), (HTR2A), the tumor necrosis factor superfamily member TL1A gene (TNFSF15). We performed a review of existent data, that studied genetic polymorphisms in IBS patients. We found that the actual IBS subgroups are not sufficient in order to identify distinct phenotypes and further in leading to new guiding principles for treatment. This sistematic review demonstrates the need for genetic studies with an increasing number of subjects, because contradictory findings in terms of IBS subtype have been reported.
Publish Date	2018-03-07 08:05
Citation	Popa SL, Dumitrascu DL, Vulturar R, Niesler B. Genetic studies in irritable bowel syndrome-status quo. World J Meta-Anal 2018; 6(1): 1-8
URL	http://www.wjgnet.com/2308-3840/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.13105/wjma.v6.i1.1

Full Article (PDF)	WJMA-6-1.pdf
Full Article (Word)	WJMA-6-1.doc
Manuscript File	37300-Review.docx
Answering Reviewers	37300-Answering reviewers.pdf
Audio Core Tip	37300-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37300-Conflict-of-interest statement.pdf
Copyright License Agreement	37300-Copyright assignment.pdf
Peer-review Report	37300-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	37300-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	37300-Scientific misconduct check.pdf
Scientific Editor Work List	37300-Scientific editor work list.pdf