Publication Name	World Journal of Hepatology
Manuscript ID	37331
Country	Pakistan

Received	2017-12-05 09:49
Peer-Review Started	2017-12-05 23:10
To Make the First Decision	2018-01-15 03:29
Return for Revision	2018-01-15 07:57
Revised	2018-02-06 22:19
Second Decision	2018-02-08 08:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-02-09 03:03
Articles in Press	2018-02-09 03:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-26 10:21
Publish the Manuscript Online	2018-03-04 12:36

ISSN	1948-5182 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon?
Manuscript Source	Invited Manuscript
All Author List	Amna Subhan Butt, Fatima Sharif and Shahab Abid
ORCID	Author(s) ORCID Number Amna Subhan Butt http://orcid.org/0000-0002-7311-4055 Fatima Sharif http://orcid.org/0000-0002-3366-9830 Shahab Abid http://orcid.org/0000-0003-2520-0378
Funding Agency and Grant Number
Corresponding Author	Shahab Abid, FACG, FCPS, MD, PhD, Professor, Section of Gastroenterology at Department of Medicine, Aga Khan University, Stadium Road, Karachi 74800, Pakistan. shahab.abid@aku.edu
Key Words	Hepatocellular carcinoma; Direct acting antivirals; Hepatitis C
Core Tip	The ground-breaking discovery of the new group of direct acting antiviral agents (DAAs) had led to a paradigm shift in the management of chronic hepatitis C (CHC). Wide variations have been observed in the studies assessing the long-term role of DAA based therapy on occurrence and recurrence of HCC. There is a need to differentiate weather the reported higher occurrence recurrence rates are due to DAA or host and disease related factors and to identify subset of individuals particularly at risk. Also, future investigations should be directed towards assessing the long-term effects of DAAs on group of patients that have not been studied thus far. Some important Centers in Europe and United States have been delaying antiviral treatment for 6 mo or more after the recent treatment for HCC. Hence, until more robust data is available, clinical practices should continue as per current guidelines in those patient groups who can benefit from DAA therapy with close surveillance of patients with advance fibrosis. Our aim is to consolidate the existing literature as well as to identify whether there is a particular subset of the population in which this phenomenon was witnessed.
Publish Date	2018-03-04 12:36
Citation	Butt AS, Sharif F, Abid S. Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon? World J Hepatol 2018; 10(2): 267-276
URL	http://www.wjgnet.com/1948-5182/full/v10/i2/267.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i2.267

Full Article (PDF)	WJH-10-267.pdf
Full Article (Word)	WJH-10-267.doc
Manuscript File	37331-Review.docx
Answering Reviewers	37331-Answering reviewers.pdf
Audio Core Tip	37331-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37331-Conflict-of-interest statement.pdf
Copyright License Agreement	37331-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	37331-Language certificate.pdf
Peer-review Report	37331-Peer-review(s).pdf
Scientific Misconduct Check	37331-Scientific misconduct check.pdf
Scientific Editor Work List	37331-Scientific editor work list.pdf