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Articles Published Processes
3/4/2018 12:36:47 PM | Browse: 1426 | Download: 1660
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Received |
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2017-12-04 20:15 |
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Peer-Review Started |
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2017-12-05 00:35 |
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To Make the First Decision |
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2017-12-11 08:21 |
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Return for Revision |
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2017-12-12 01:17 |
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Revised |
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2018-01-11 12:39 |
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Second Decision |
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2018-01-31 06:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-02-09 01:33 |
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Articles in Press |
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2018-02-09 01:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-02-28 06:34 |
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Publish the Manuscript Online |
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2018-03-04 12:36 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Hepatitis C virus: Morphogenesis, infection and therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vladimir Alexei Morozov and Sylvie Lagaye |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sylvie Lagaye, DSc, PhD, Academic Research, Senior Scientist, Department of Immunology, Institut Pasteur, INSERM U1223, 25-28 rue du Dr Roux, Paris 75015, France. sylvie.lagaye@inserm.fr |
| Key Words |
Hepatitis C virus; Transmission; Molecular biology; Pathogenesis; In vitro and ex vivo models of hepatitis C virus infection; Treatment |
| Core Tip |
Brief overviews on epidemiology of hepatitis C virus (HCV), virus morphology and life cycle are presented. A special attention was focused on in vitro and in vivo models that are currently used to study the HCV infection. In fact, extensive use of existing models and creating a new ones is a way to reveal important events in the virus interaction with target cells. In particular, uncover of these interactions might shed light on the mechanism behind virus induced pathogenesis and chronicity, and by that contribute to the development of new drugs and prophylactic vaccines. Recently, the new multiple therapies with a pan-genotypic activity appeared on the market. It is worth mentioning, that there is no cross-resistance among the various classes of direct antiviral agents. The new agents (third generation) and even new targets (entry inhibitors, release inhibitors) being studied, should allow to cure all patients in the mid-term, hoping that they will have equal access to therapy. |
| Publish Date |
2018-03-04 12:36 |
| Citation |
Morozov VA, Lagaye S. Hepatitis C virus: Morphogenesis, infection and therapy. World J Hepatol 2018; 10(2): 186-212 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i2/186.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i2.186 |
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