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2/9/2018 7:24:29 AM | Browse: 1129 | Download: 1599
Publication Name World Journal of Gastroenterology
Manuscript ID 37443
Country/Territory Italy
Received
2017-12-06 17:05
Peer-Review Started
To Make the First Decision
2017-12-12 02:46
Return for Revision
2017-12-12 08:05
Revised
2017-12-13 16:16
Second Decision
2017-12-19 11:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-12-20 02:12
Articles in Press
2017-12-20 02:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-02-08 08:03
Publish the Manuscript Online
2018-02-09 07:24
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biology
Manuscript Type Basic Study
Article Title Glucose transporter expression in the human colon
Manuscript Source Unsolicited Manuscript
All Author List Flavia Merigo, Alessandro Brandolese, Sonia Facchin, Silvia Missaggia, Paolo Bernardi, Federico Boschi, Renata D'Incà, Edoardo Vincenzo Savarino, Andrea Sbarbati and Giacomo Carlo Sturniolo
ORCID
Author(s) ORCID Number
Flavia Merigo http://orcid.org/0000-0002-6919-7169
Alessandro Brandolese http://orcid.org/0000-0003-2977-992X
Sonia Facchin http://orcid.org/0000-0002-6774-590X
Silvia Missaggia http://orcid.org/0000-0002-8437-379X
Paolo Bernardi http://orcid.org/0000-0002-1225-9525
Federico Boschi http://orcid.org/0000-0001-9623-6859
Renata D'Incà http://orcid.org/0000-0003-1169-1890
Edoardo Vincenzo Savarino http://orcid.org/0000-0002-3187-2894
Andrea Sbarbati http://orcid.org/0000-0002-0954-2119
Giacomo Carlo Sturniolo http://orcid.org/0000-0002-2398-110X
Funding Agency and Grant Number
Corresponding Author Flavia Merigo, BSc, Human Anatomy and Histology Section, Department of Neuroscience, Biomedicine and Movement, Human Anatomy and Histology Section, University of Verona, Strada Le Grazie, 8, Verona 37134, Italy. flavia.merigo@univr.it
Key Words Ulcerative colitis; Colon; Crohn’s disease; Glucose transporter; LYVE-1, Immunohistochemistry
Core Tip Our study demonstrates that GLUT2, SGLT1, and GLUT5 glucose transporters are expressed in the colorectal mucosa in controls and patients with inflammatory bowel disease (IBD). In addition, it provides first evidence that GLUT5 expression is associated with lymphatic vessels in controls and IBD patients. GLUT5-immunoreactive vessels were isolated or clustered in specific areas. We interpreted the presence of clusters as a pattern related to proliferative zones. As GLUT5 is the main fructose transporter, fructose may have a role in the atypical aggregation of lymphatic vessels. This novel finding yields further insight into the characterization of lymphatic vasculature, whose dysfunction is a long-recognized feature in humans with IBD.
Publish Date 2018-02-09 07:24
Citation Merigo F, Brandolese A, Facchin S, Missaggia S, Bernardi P, Boschi F, D’Incà R, Savarino EV, Sbarbati A, Sturniolo GC. Glucose transporter expression in the human colon. World J Gastroenterol 2018; 24(7): 775-793
URL http://www.wjgnet.com/1007-9327/full/v24/i7/775.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i7.775
Full Article (PDF) WJG-24-775.pdf
Full Article (Word) WJG-24-775.doc
Manuscript File 37443-Review.docx
Answering Reviewers 37443-Answering reviewers.pdf
Audio Core Tip 37443-Audio core tip.mp3
Biostatistics Review Certificate 37443-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37443-Conflict-of-interest statement.pdf
Copyright License Agreement 37443-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 37443-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 37443-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 37443-Language certificate.pdf
Supplementary Material 37443-Supplementary-Material-revision.docx
Peer-review Report 37443-Peer-review(s).pdf
Scientific Misconduct Check 37443-Scientific misconduct check.pdf
Scientific Editor Work List 37443-Scientific editor work list.pdf