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Articles Published Processes
2/27/2018 5:35:20 AM | Browse: 1167 | Download: 1798
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Received |
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2017-12-13 09:32 |
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Peer-Review Started |
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2017-12-13 10:44 |
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To Make the First Decision |
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2017-12-27 02:22 |
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Return for Revision |
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2017-12-27 09:48 |
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Revised |
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2018-01-12 13:09 |
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Second Decision |
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2018-01-19 09:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-01-19 18:40 |
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Articles in Press |
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2018-01-19 18:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-02-01 03:42 |
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Typeset the Manuscript |
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2018-02-21 04:26 |
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Publish the Manuscript Online |
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2018-02-27 05:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei-Min Yu, Ke-Jia Zhao, Shuang-Shuang Wang, Xi Wang and Bin Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81470814 |
| National Natural Science Foundation of China |
81400594 |
| Zhejiang Provincial Natural Science Foundation of China |
LQ14H160014 |
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| Corresponding Author |
Bin Lu, MD, PhD, Doctor, Doctor, Professor, Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn |
| Key Words |
Irritable bowel syndrome; Metabolite; Gas chromatography/mass spectrometry; Clostridium butyricum |
| Core Tip |
In this study, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with irritable bowel syndrome (IBS). A total of 14 differentially excreted metabolites were identified, and phenylalanine (a major metabolite induced by stress) was found to be the most relevant of these metabolites. Between the IBS group and IBS + C. butyricum group, 10 differentially excreted metabolites were identified, and pantothenate and coenzyme A (CoA) biosynthesis metabolites, as well as steroid hormone biosynthesis metabolites were found to be significantly relevant. Thus, supplementation with C. butyricum to IBS mice had beneficial effects through modulation of host metabolism. |
| Publish Date |
2018-02-27 05:35 |
| Citation |
Yu LM, Zhao KJ, Wang SS, Wang X, Lu B. Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome. World J Gastroenterol 2018; 24(8): 894-904 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i8/894.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i8.894 |
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