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2/6/2018 3:22:41 AM | Browse: 913 | Download: 777
Publication Name World Journal of Gastroenterology
Manuscript ID 37600
Country/Territory United States
Received
2017-12-20 17:32
Peer-Review Started
2017-12-21 02:43
To Make the First Decision
2017-12-27 01:53
Return for Revision
2017-12-27 03:12
Revised
2018-01-03 16:40
Second Decision
2018-01-18 11:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-01-18 15:07
Articles in Press
2018-01-18 15:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-01-31 10:07
Publish the Manuscript Online
2018-02-06 03:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease
Manuscript Source Invited Manuscript
All Author List Robert C Sharp, Shazia A Beg and Saleh A Naser
ORCID
Author(s) ORCID Number
Robert C Sharp http://orcid.org/0000-0002-5167-8941
Shazia A Beg http://orcid.org/0000-0002-4096-9452
Saleh A Naser http://orcid.org/0000-0001-9222-4527
Funding Agency and Grant Number
Funding Agency Grant Number
the Florida Legislative Grant and the Crohn’s Disease Grant Funded by the State of Florida (in part)
Corresponding Author Saleh A Naser, PhD, Professor, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4110 Libra Drive, Orlando, FL 32816, United States. saleh.naser@ucf.edu
Key Words Crohn’s disease; PTPN2; PTPN22; PTPN2/22; Mycobacteria; Single nucleotide polymorphisms
Core Tip Knowledge of the pathophysiology of Crohn’s disease (CD) is vital in the development of new diagnosis techniques and treatments for the disease. Our study involves the investigation of single nucleotide polymorphisms (SNPs) in protein tyrosine phosphatase non-receptor type 2 and 22 (PTPN2/22) and their effects on susceptibility to mycobacteria species and the elevation of pro-inflammatory cytokines. Our data demonstrates that SNPs in PTPN2/22 lead to less negative regulation in T-cells and increase susceptibility to mycobacteria, thus increasing inflammation and apoptosis in intestinal tissues. Personalized treatment could be accomplished by genetic testing and antibiotic treatment for mycobacteria in CD patients.
Publish Date 2018-02-06 03:22
Citation Sharp RC, Beg SA, Naser SA. Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease. World J Gastroenterol 2018; 24(6): 657-670
URL http://www.wjgnet.com/1007-9327/full/v24/i6/657.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i6.657
Full Article (PDF) WJG-24-657.pdf
Full Article (Word) WJG-24-657.doc
Manuscript File 37600-Review.docx
Answering Reviewers 37600-Answering reviewers.pdf
Audio Core Tip 37600-Audio core tip.wav
Conflict-of-Interest Disclosure Form 37600-Conflict-of-interest statement.pdf
Copyright License Agreement 37600-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 37600-Institutional review board statement.pdf
Peer-review Report 37600-Peer-review(s).pdf
Scientific Misconduct Check 37600-Scientific misconduct check.pdf
Scientific Editor Work List 37600-Scientific editor work list.pdf