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Articles Published Processes
4/27/2018 3:25:40 AM | Browse: 1042 | Download: 1572
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Received |
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2018-01-25 16:03 |
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Peer-Review Started |
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2018-01-26 01:41 |
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To Make the First Decision |
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2018-02-24 01:06 |
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Return for Revision |
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2018-02-27 01:44 |
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Revised |
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2018-03-11 12:12 |
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Second Decision |
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2018-03-16 10:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-03-18 01:43 |
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Articles in Press |
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2018-03-18 01:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-03-28 20:31 |
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Typeset the Manuscript |
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2018-04-25 11:11 |
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Publish the Manuscript Online |
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2018-04-27 03:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Xia Guo, Nan Ye, Ping Yan, Min-Yue Qiu, Ji Zhang, Zi-Gang Shen, Hai-Yang He, Zhi-Qiang Tian, Hong-Li Li and Jin-Tao Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81271813 |
| National Natural Science Foundation of China |
81570497 |
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| Corresponding Author |
Jin-Tao Li, PhD, Professor, Department of Preventive Medicine, Institute of Tropical Medicine, Gaotanyan Street 30, Shapingba District, Chongqing 400038, China. ljtqms@qq.com |
| Key Words |
NaCl; Inflammatory bowel disease; Macrophage; CD4+IFN-γ+IL-17+ T cell; p38/MAPK |
| Core Tip |
NaCl, as an indispensable environmental factor, evokes both innate and adaptive immune proinflammation cell activation in mice affected by dextran sulfate sodium (DSS)-induced colitis. Proinflammatory CD4+ cells in DSS- and NaCl-treated mice are mainly double-positive IL-17+IFN-γ+ T cells. Macrophage depletion significantly alleviates DSS-induced colitis. M1 macrophages play an important role in the proinflammatory effect of NaCl in the mouse gut. NaCl promotes M1 proinflammatory gene expression in lipopolysaccharide-activated peritoneal macrophage. The mechanism by which NaCl promotes DSS-induced colitis involves up-regulation of the p38/MAPK axis. |
| Publish Date |
2018-04-27 03:25 |
| Citation |
Guo HX, Ye N, Yan P, Qiu MY, Zhang J, Shen ZG, He HY, Tian ZQ, Li HL, Li JT. Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice. World J Gastroenterol 2018; 24(16): 1779-1794 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i16/1779.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i16.1779 |
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