| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews and Cheng-Shiun Leu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
DK077734 |
| Children’s Digestive Health and Nutrition Foundation (now known as North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Foundation)/Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Award for New Investigators |
CDHNF-06-002 (NG) |
| Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Career Development Award |
Award ID 1743 (NG) |
| University of California San Francisco Department of Pediatrics Pediatric Clinical Research Center Clinical Research Pilot Funding Award (NG), and National Institutes of Health/National Center for Research Resources University of California San Francisco-Clinical and Translational Science Institute |
UL1 RR024131 |
|
| Corresponding Author |
Neera Gupta, MD, Associate Professor, Division of Gastroenterology and Nutrition, Department of Pediatrics, Weill Cornell Medicine, Weill Cornell Medicine, 505 East 70th Street, Helmsley Tower, 3rd Floor, New York, NY 10021, United States. neg9020@med.cornell.edu |
| Key Words |
Inflammatory bowel disease; Azathioprine/6-mercaptopurine; Biologics; Nutrition |
| Core Tip |
Azathioprine/6-mercaptopurine were negatively associated with specific anthropometric parameters, suggesting a possible negative effect vs poor efficacy of thiopurines in pediatric Crohn’s disease (CD). Infliximab was positively associated with standardized height in females only, suggesting a possible sex difference in response to infliximab from the standpoint of statural growth in pediatric CD. Specific serum biomarkers were associated with standardized height in males only, supporting that inflammation has a more detrimental effect on statural growth in males with pediatric CD. |
| Publish Date |
2018-05-11 10:51 |
| Citation |
Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS. Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease. World J Gastroenterol 2018; 24(18): 2036-2046 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i18/2036.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i18.2036 |
