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5/11/2018 10:51:26 AM | Browse: 233 | Download: 155
Publication Name World Journal of Gastroenterology
Manuscript ID 38048
Country of Manuscript Source United States
Received
2018-02-03 02:16
Peer-Review Started
2018-02-03 12:42
To Make the First Decision
2018-02-24 00:42
Return for Revision
2018-02-24 03:01
Revised
2018-04-12 10:59
Second Decision
2018-04-25 10:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-26 02:17
Articles in Press
2018-04-26 02:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-05-10 08:52
Publish the Manuscript Online
2018-05-11 10:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease
Manuscript Source Unsolicited Manuscript
All Author List Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews and Cheng-Shiun Leu
ORCID
Author(s) ORCID Number
Neera Gupta http://orcid.org/0000-0002-9571-3913
Robert H Lustig http://orcid.org/0000-0001-6983-2639
Cewin Chao http://orcid.org/0000-0002-5711-926X
Eric Vittinghoff http://orcid.org/0000-0001-8535-0920
Howard Andrews http://orcid.org/0000-0002-7726-0551
Cheng-Shiun Leu http://orcid.org/0000-0002-0301-8316
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health DK077734
Children’s Digestive Health and Nutrition Foundation (now known as North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Foundation)/Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Award for New Investigators CDHNF-06-002 (NG)
Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Career Development Award Award ID 1743 (NG)
University of California San Francisco Department of Pediatrics Pediatric Clinical Research Center Clinical Research Pilot Funding Award (NG), and National Institutes of Health/National Center for Research Resources University of California San Francisco-Clinical and Translational Science Institute UL1 RR024131
Corresponding author Neera Gupta, MD, Associate Professor, Division of Gastroenterology and Nutrition, Department of Pediatrics, Weill Cornell Medicine, Weill Cornell Medicine, 505 East 70th Street, Helmsley Tower, 3rd Floor, New York, NY10021, United States. neg9020@med.cornell.edu
Keywords Inflammatory bowel disease; Azathioprine/6-mercaptopurine; Biologics; Nutrition
Core Tip Azathioprine/6-mercaptopurine were negatively associated with specific anthropometric parameters, suggesting a possible negative effect vs poor efficacy of thiopurines in pediatric Crohn’s disease (CD). Infliximab was positively associated with standardized height in females only, suggesting a possible sex difference in response to infliximab from the standpoint of statural growth in pediatric CD. Specific serum biomarkers were associated with standardized height in males only, supporting that inflammation has a more detrimental effect on statural growth in males with pediatric CD.
Publish Date 2018-05-11 10:51
Citation Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS. Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease. World J Gastroenterol 2018; 24(18): 2036-2046
Url http://www.wjgnet.com/1007-9327/full/v24/i18/2036.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i18.2036
Full Article (PDF) WJG-24-2036.pdf
Full Article (Word) WJG-24-2036.doc
Manuscript File 38048-Review.docx
Answering Reviewers 38048-Answering reviewers.pdf
Audio Core Tip 38048-Audio core tip.mp3
Biostatistics Review Certificate 38048-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38048-Conflict-of-interest statement.pdf
Copyright License Agreement 38048-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 38048-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 38048-Institutional review board statement.pdf
Supplementary Material 38048-Supplementary-Material-revision.pdf
Peer-review Report 38048-Peer-review(s).pdf
Scientific Misconduct Check 38048-Scientific misconduct check.pdf
Scientific Editor Work List 38048-Scientific editor work list.pdf