Publication Name	World Journal of Gastroenterology
Manuscript ID	38130
Country	China

Received	2018-01-27 12:52
Peer-Review Started	2018-01-28 09:52
To Make the First Decision	2018-02-10 08:26
Return for Revision	2018-02-11 04:20
Revised	2018-02-12 09:31
Second Decision	2018-02-25 10:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-02-25 23:02
Articles in Press	2018-02-25 23:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-03-05 22:09
Typeset the Manuscript	2018-03-15 09:11
Publish the Manuscript Online	2018-03-16 12:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Functional macrophages and gastrointestinal disorders
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Hong Liu, Yue Ding, Chen-Chen Gao, Li-Sheng Li, Yue-Xiu Wang and Jing-Dong Xu
ORCID	Author(s) ORCID Number Yue-Hong Liu http://orcid.org/https://orcid.org/0000-0002-6618-3511 Yue Ding http://orcid.org/https://orcid.org/0000-0001-6291-6848 Chen-Chen Gao http://orcid.org/https://orcid.org/0000-0002-3730-0272 Li-Sheng Li http://orcid.org/https://orcid.org/0000-0002-7255-6863 Yue-Xiu Wang http://orcid.org/https://orcid.org/0000-0002-3243-3092 Jing-Dong Xu http://orcid.org/https://orcid.org/0000-0003-4546-563X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81274173 National Natural Science Foundation of China 81673671 National Natural Science Foundation of China 81270443 Beijing National Science Foundation 7122017
Corresponding Author	Jing-Dong Xu, PhD, Assistant Professor, School of Basic Medical Sciences, Beijing Capital Medical University, No.10, Xitoutiao, Youanmenwai, Fengtai district, Beijing 100069, China. xujingdong@163.com
Key Words	Macrophages; Homeostasis; Inflammatory bowel disease; Gastrointestinal tumors; Therapeutic targets
Core Tip	The manuscript involves three components. First, after briefly describing the origin of macrophages (MΦ), it summarizes their general biologic features and common functions. The second component reveals the differences between resident MΦ in the intestine and those in other tissues. Notably, we depicted how resident MΦ participate in maintaining intestinal homeostasis and why they can maintain intestinal health by comparison between each of these distinct features. The third part discusses how the deficiency of this anti-inflammatory system leads to autoimmune diseases. However, we also discuss the many details of why intestinal MΦ and the underlying mechanism of inflammatory bowel disease and gut tumors remain obscure.
Publish Date	2018-03-16 12:27
Citation	Liu YH, Ding Y, Gao CC, Li LS, Wang YX, Xu JD. Functional macrophages and gastrointestinal disorders. World J Gastroenterol 2018; 24(11): 1181-1195
URL	http://www.wjgnet.com/1007-9327/full/v24/i11/1181.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i11.1181

Full Article (PDF)	WJG-24-1181.pdf
Full Article (Word)	WJG-24-1181.doc
Manuscript File	38130-Review.docx
Answering Reviewers	38130-Answering reviewers.pdf
Audio Core Tip	38130-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	38130-Conflict-of-interest statement.pdf
Copyright License Agreement	38130-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38130-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	38130-Language certificate.pdf
Peer-review Report	38130-Peer-review(s).pdf
Scientific Misconduct Check	38130-Scientific misconduct check.pdf
Scientific Editor Work List	38130-Scientific editor work list.pdf