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Articles Published Processes
4/4/2018 1:15:45 PM | Browse: 1080 | Download: 1733
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Received |
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2018-01-28 03:15 |
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Peer-Review Started |
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2018-01-28 09:51 |
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To Make the First Decision |
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2018-02-10 08:24 |
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Return for Revision |
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2018-02-11 04:34 |
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Revised |
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2018-02-16 22:11 |
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Second Decision |
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2018-02-25 10:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-02-25 23:01 |
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Articles in Press |
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2018-02-25 23:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-04-03 05:51 |
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Publish the Manuscript Online |
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2018-04-04 13:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Dissecting the molecular pathophysiology of drug-induced liver injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Ye, Leonard J Nelson, Manuel Gómez del Moral, Eduardo Martínez-Naves and Francisco Javier Cubero |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MINECO |
RyC2014-15242 |
| MINECO |
SAF2016-78711 |
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| Corresponding Author |
Francisco Javier Cubero, BSc, MSc, PhD, Assistant Professor, Department of Immunology, Complutense University School of Medicine, Plaza Ramón y Cajal s/n, Madrid 28040, Spain. fcubero@ucm.es |
| Key Words |
Signaling pathways; Acetaminophen; Drug-induced liver injury; Cell death; Reactive oxygen species |
| Core Tip |
Drug-induced liver injury (DILI) represents a broad spectrum of clinical manifestations, and is generally divided into two subtypes: intrinsic and idiosyncratic hepatotoxicity. Drugs and their reactive metabolites covalently bind to mitochondria and cause direct hepatic toxicity through accumulation of oxidative stress (ROS and RNS), endoplasmic reticulum stress and mitochondrial dysfunction, ultimately leading to cell death. The innate and adaptive immune responses also play an important role in the occurrence of idiosyncratic immunological reactions towards the drugs. In this review, we discuss the pathophysiological mechanisms underlying DILI, specific signaling pathways and the common forms of hepatocyte death. |
| Publish Date |
2018-04-04 13:15 |
| Citation |
Ye H, Nelson LJ, Gómez del Moral M, Martínez-Naves E, Cubero FJ. Dissecting the molecular pathophysiology of drug-induced liver injury. World J Gastroenterol 2018; 24(13): 1373-1385 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i13/1373.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i13.1373 |
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