| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yusuke Ozawa, Takafumi Tamura, Yohei Owada, Yoshio Shimizu, Akira Kemmochi, Katsuji Hisakura, Takashi Matsuzaka, Hitoshi Shimano, Hiroko Isoda and Nobuhiro Ohkohchi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI |
26861059 |
| Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI |
16K10489 |
|
| Corresponding Author |
Nobuhiro Ohkohchi, MD, PhD, Professor, Surgeon, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tennoudai 1-1-1, Tsukuba-shi 305-8575, ibaraki-ken, Japan. nokochi3@md.tsukuba.ac.jp |
| Key Words |
Hepatectomy; Liver regeneration; Residual liver; Liver proliferation; Nonalcoholic steatohepatitis |
| Core Tip |
We report whether the liver resection volume in the nonalcoholic steatohepatitis (NASH) model influences surgical outcome. The population of patients with NASH has been increasing. However, few animal models fully reflect both the histopathology and pathophysiology of NASH in humans. We established a novel experimental NASH model that exhibited the same characteristics as NASH in humans. This study elucidates the metabolism of the residual liver after a hepatectomy with NASH. Compared with normal liver, the residual NASH liver function is impaired, especially its regenerative ability. Therefore, a larger residual volume is required to maintain liver function in NASH liver after partial hepatectomy. |
| Publish Date |
2018-04-19 07:56 |
| Citation |
Ozawa Y, Tamura T, Owada Y, Shimizu Y, Kemmochi A, Hisakura K, Matsuzaka T, Shimano H, Isoda H, Ohkohchi N. Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis. World J Gastroenterol 2018; 24(15): 1622-1631 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i15/1622.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i15.1622 |
