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6/11/2018 1:12:19 AM | Browse: 732 | Download: 1104
Publication Name World Journal of Gastroenterology
Manuscript ID 38348
Country/Territory China
Received
2018-02-12 04:17
Peer-Review Started
2018-02-12 06:25
To Make the First Decision
2018-02-24 01:20
Return for Revision
2018-02-24 09:22
Revised
2018-03-08 13:27
Second Decision
2018-04-13 08:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-15 23:20
Articles in Press
2018-04-15 23:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-05-21 19:32
Typeset the Manuscript
2018-06-04 10:55
Publish the Manuscript Online
2018-06-11 01:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Jun Zhang, Yue Wu, Yu-Hang Lin, Shuai Guo, Pei-Fang Ning, Zhi-Chao Zheng, Yue Wang and Yan Zhao
ORCID
Author(s) ORCID Number
Yan Zhao http://orcid.org/0000-0002-7760-916X
Funding Agency and Grant Number
Funding Agency Grant Number
Liaoning S&T Project 2015020269
Doctor fund of Liaoning Province Cancer Hospital & Institute Z1410
Corresponding Author Yan Zhao, PhD, Professor, Surgeon, Department of Gastric Cancer, Liaoning Cancer Hospital and Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. surgoenzhangjun@hotmail.com
Key Words Gastric cancer; Hypoxia inducible factor-1α; Prolyl 4-hydroxylase beta polypeptide; Overall survival; Clinicopathological predictors; Disease free survival
Core Tip The progression of gastric cancer is closely related to the hypoxic tumor microenvironment. In the present study, we found the expression levels of prolyl 4-hydroxylase beta (P4HB) and hypoxia-inducible factor-1α (HIF-1α) were significantly increased in gastric cancer tissue, and patients with high P4HB and HIF-1α expression had an increased risk of death and relapse compared with patients with low P4HB and HIF-1α expression after adjusting for potential confounders. Based on our research, we suggest that higher expression of P4HB and HIF-1α promotes risk of death and relapse and may act as an indicator of prognosis in patients with gastric cancer.
Publish Date 2018-06-11 01:12
Citation Zhang J, Wu Y, Lin YH, Guo S, Ning PF, Zheng ZC, Wang Y, Zhao Y. Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer. World J Gastroenterol 2018; 24(22): 2381-2391
URL http://www.wjgnet.com/1007-9327/full/v24/i22/2381.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i22.2381
Full Article (PDF) WJG-24-2381.pdf
The ARRIVE Guidelines 38348-The ARRIVE guidelines.pdf
Manuscript File 38348-Review.docx
Answering Reviewers 38348-Answering reviewers.pdf
Audio Core Tip 38348-Audio core tip.mp3
Biostatistics Review Certificate 38348-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 38348-Conflict-of-interest statement.pdf
Copyright License Agreement 38348-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38348-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 38348-Institutional Animal Care and Use Committee Approval Form or Document.JPG
Institutional Review Board Approval Form or Document 38348-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 38348-Language certificate.pdf
Peer-review Report 38348-Peer-review(s).pdf
Scientific Misconduct Check 38348-Scientific misconduct check.pdf
Scientific Editor Work List 38348-Scientific editor work list.pdf