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Articles Published Processes
6/11/2018 1:12:19 AM | Browse: 821 | Download: 1471
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Received |
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2018-02-12 04:17 |
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Peer-Review Started |
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2018-02-12 06:25 |
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To Make the First Decision |
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2018-02-24 01:20 |
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Return for Revision |
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2018-02-24 09:22 |
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Revised |
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2018-03-08 13:27 |
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Second Decision |
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2018-04-13 08:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-04-15 23:20 |
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Articles in Press |
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2018-04-15 23:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-05-21 19:32 |
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Typeset the Manuscript |
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2018-06-04 10:55 |
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Publish the Manuscript Online |
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2018-06-11 01:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Zhang, Yue Wu, Yu-Hang Lin, Shuai Guo, Pei-Fang Ning, Zhi-Chao Zheng, Yue Wang and Yan Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Liaoning S&T Project |
2015020269 |
| Doctor fund of Liaoning Province Cancer Hospital & Institute |
Z1410 |
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| Corresponding Author |
Yan Zhao, PhD, Professor, Surgeon, Department of Gastric Cancer, Liaoning Cancer Hospital and Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. surgoenzhangjun@hotmail.com |
| Key Words |
Gastric cancer; Hypoxia inducible factor-1α; Prolyl 4-hydroxylase beta polypeptide; Overall survival; Clinicopathological predictors; Disease free survival |
| Core Tip |
The progression of gastric cancer is closely related to the hypoxic tumor microenvironment. In the present study, we found the expression levels of prolyl 4-hydroxylase beta (P4HB) and hypoxia-inducible factor-1α (HIF-1α) were significantly increased in gastric cancer tissue, and patients with high P4HB and HIF-1α expression had an increased risk of death and relapse compared with patients with low P4HB and HIF-1α expression after adjusting for potential confounders. Based on our research, we suggest that higher expression of P4HB and HIF-1α promotes risk of death and relapse and may act as an indicator of prognosis in patients with gastric cancer. |
| Publish Date |
2018-06-11 01:12 |
| Citation |
Zhang J, Wu Y, Lin YH, Guo S, Ning PF, Zheng ZC, Wang Y, Zhao Y. Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer. World J Gastroenterol 2018; 24(22): 2381-2391 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i22/2381.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i22.2381 |
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