Publication Name	World Journal of Gastroenterology
Manuscript ID	3843
Country	Japan

Received	2013-05-28 09:33
Peer-Review Started	2013-05-29 15:27
First Decision by Editorial Office Director
Return for Revision	2013-06-20 16:38
Revised	2013-07-16 12:06
Publication Fee Transferred
Second Decision by Editor	2013-08-19 12:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-08-20 00:16
Articles in Press
Edit the Manuscript by Language Editor	2014-03-15 17:26
Typeset the Manuscript	2014-03-25 20:41
Publish the Manuscript Online	2014-04-04 15:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis
Manuscript Source	Invited Manuscript
All Author List	Mio Kobayashi, Yuko Kakuda, Kenichi Harada, Yasunori Sato, Motoko Sasaki, Hiroko Ikeda, Mitsuhiro Terada, Munenori Mukai, Shuichi Kaneko and Yasuni Nakanuma
Funding Agency and Grant Number	Funding Agency Grant Number Primary Biliary Cirrhosis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan Department of Human and Environmental Sciences, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
Corresponding Author	Yasuni Nakanuma, MD, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Takaramachi 13-1, Kanazawa 920-8640, Japan. nakanuma@staff.kanazawa-u.ac.jp
Key Words	Primary biliary cirrhosis; Autoimmune hepatitis; Interface hepatitis; Lobular hepatitis; Plasma cell subclass
Core Tip	Primary biliary cirrhosis (PBC) can sometimes present with features of autoimmune hepatitis (AIH). Therefore, the clinicopathological features and immunophenotypes of infiltrated mononuclear cells of AIH and PBC with AIH features were examined. Lobular hepatitis, hepatitic rosette formation, and emperipolesis were more frequent in AIH than PBC. The degree of mononuclear cell infiltration correlated well with hepatitis. Furthermore, elevation of aspartate aminotransferase levels correlated well with necroinflammation and infiltration of mononuclear cells in PBC, which tended to be IgM-predominant. These results suggest that hepatocellular injuries in AIH and PBC may not be identical.
Publish Date	2014-04-04 15:11
Citation	Kobayashi M, Kakuda Y, Harada K, Sato Y, Sasaki M, Ikeda H, Terada M, Mukai M, Kaneko S, Nakanuma Y. Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis. World J Gastroenterol 2014; 20(13): 3597-3608
URL	http://www.wjgnet.com/1007-9327/full/v20/i13/3597.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i13.3597

Full Article (PDF)	WJG-20-3597.pdf
Full Article (Word)	WJG-20-3597.doc
Manuscript File	3843-Review.docx
Answering Reviewers	3843-Answering reviewers.PDF
Copyright License Agreement	3843-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	3843-Language certificate.pdf
Peer-review Report	3843-Peer reviewer(s).pdf
Scientific Editor Work List	3843-Scientific editor work list.doc