| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mio Kobayashi, Yuko Kakuda, Kenichi Harada, Yasunori Sato, Motoko Sasaki, Hiroko Ikeda, Mitsuhiro Terada, Munenori Mukai, Shuichi Kaneko and Yasuni Nakanuma |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Primary Biliary Cirrhosis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan |
|
| Department of Human and Environmental Sciences, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan |
|
|
| Corresponding Author |
Yasuni Nakanuma, MD, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Takaramachi 13-1, Kanazawa 920-8640, Japan. nakanuma@staff.kanazawa-u.ac.jp
|
| Key Words |
Primary biliary cirrhosis; Autoimmune hepatitis; Interface hepatitis; Lobular hepatitis; Plasma cell subclass |
| Core Tip |
Primary biliary cirrhosis (PBC) can sometimes present with features of autoimmune hepatitis (AIH). Therefore, the clinicopathological features and immunophenotypes of infiltrated mononuclear cells of AIH and PBC with AIH features were examined. Lobular hepatitis, hepatitic rosette formation, and emperipolesis were more frequent in AIH than PBC. The degree of mononuclear cell infiltration correlated well with hepatitis. Furthermore, elevation of aspartate aminotransferase levels correlated well with necroinflammation and infiltration of mononuclear cells in PBC, which tended to be IgM-predominant. These results suggest that hepatocellular injuries in AIH and PBC may not be identical. |
| Publish Date |
2014-04-04 15:11 |
| Citation |
Kobayashi M, Kakuda Y, Harada K, Sato Y, Sasaki M, Ikeda H, Terada M, Mukai M, Kaneko S, Nakanuma Y. Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis. World J Gastroenterol 2014; 20(13): 3597-3608 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i13/3597.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i13.3597 |
