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Articles Published Processes
5/11/2018 10:51:26 AM | Browse: 1002 | Download: 1935
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Received |
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2018-03-07 01:36 |
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Peer-Review Started |
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2018-03-07 06:10 |
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To Make the First Decision |
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2018-04-03 00:59 |
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Return for Revision |
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2018-04-06 09:04 |
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Revised |
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2018-04-13 21:15 |
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Second Decision |
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2018-04-23 05:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-04-23 16:36 |
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Articles in Press |
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2018-04-23 16:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-05-10 08:53 |
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Publish the Manuscript Online |
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2018-05-11 10:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Maria Carolina S Mendes, Daiane SM Paulino, Sandra R Brambilla, Juliana A Camargo, Gabriela F Persinoti and José Barreto Campello Carvalheira |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation |
07607-8/2013 |
| National Research Council |
150127/2016-2 |
| National Research Council |
306821/2010-9 |
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| Corresponding Author |
José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Internal Medicine - Division of oncology, UNICAMP, Tessália Vieira Camargo, S/N, Campinas 13083-970, Sao Paulo, Brazil. jbcc@g.unicamp.br |
| Key Words |
Intestinal microbiota; Chemoprevention; Lactobacillus acidophilus; Lactobacillus rhamnosus; Bifidobacterium bifidum |
| Core Tip |
Intestinal microbiota has an essential role in carcinogenesis, acting in promotion of inflammation, proliferation and neoplastic progression. Probiotic supplementation is an alternative means of favourably modulating the intestinal microbiota. In this study, we investigate the effect of supplementation with a Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum mixture during the development of an experimental model of colitis-associated colon cancer. Probiotic supplementation on colorectal cancer changed the microbiota and reduced inflammation in the colon, probably by regulating the inflammatory response, and reducing inflammatory cell infiltration by lowering chemokine expression, thus preventing colitis. |
| Publish Date |
2018-05-11 10:51 |
| Citation |
Mendes MC, Paulino DS, Brambilla SR, Camargo JA, Persinoti GF, Carvalheira JB. Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice. World J Gastroenterol 2018; 24(18): 1995-2008 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i18/1995.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i18.1995 |
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