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9/25/2018 3:44:36 AM | Browse: 239 | Download: 246
Publication Name World Journal of Gastroenterology
Manuscript ID 38869
Country/Territory United States
2018-03-25 08:24
Peer-Review Started
2018-03-25 11:40
To Make the First Decision
2018-04-11 06:42
Return for Revision
2018-04-18 07:10
2018-04-24 01:17
Second Decision
2018-05-04 08:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-05-05 23:53
Articles in Press
2018-05-05 23:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-09-19 06:31
Publish the Manuscript Online
2018-09-25 03:44
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Review
Article Title Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis
Manuscript Source Invited Manuscript
All Author List Fang Yang and Guo-Xun Chen
Author(s) ORCID Number
Fang Yang http://orcid.org/0000-0002-7092-2532
Guo-Xun Chen http://orcid.org/0000-0001-6226-4050
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 31401510
Corresponding author Guo-Xun Chen, MD, PhD, Associate Professor, Research Scientist, Department of Nutrition, University of Tennessee at Knoxville, Room 229, Jessie Harris Building, 1215 West Cumberland Avenue, TN, Knoxville37996, United States. gchen6@utk.edu
Keywords Autotaxin; Lysophosphatidic acid receptors; Obesity; Lysophosphatidic acid; Insulin resistance; Liver fibrosis
Core Tip Lysophosphatidic acid (LPA) is mainly derived from hydrolysis of lysophosphatidylcholine, a process mediated by lysophospholipase D activity in proteins such as autotaxin (ATX). The binding of LPA to its receptors LPA1-6 activates multiple cellular signaling pathways and leads to changes. Studies using genetically modified animals have begun to reveal the roles of LPA pathways in metabolic active tissues and organs. The present review summarized recent progresses in the studies of extracellular and intracellular LPA production pathways; the functions, structural and biochemical properties of ATX and LPA receptors. Furthermore, the potential roles of LPA production and LPA receptor signaling pathways in obesity, insulin resistance and liver fibrosis are discussed.
Publish Date 2018-09-25 03:44
Citation Yang F, Chen GX. production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis. World J Gastroenterol 2018; 24(36): 4132-4151
Url http://www.wjgnet.com/1007-9327/full/v24/i36/4132.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i36.4132
Full Article (PDF) WJG-24-4132.pdf
Full Article (Word) WJG-24-4132.doc
Manuscript File 38869-Review.docx
Answering Reviewers 38869-Answering reviewers.pdf
Audio Core Tip 38869-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 38869-Conflict-of-interest statement.pdf
Copyright License Agreement 38869-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38869-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 38869-Language certificate.pdf
Peer-review Report 38869-Peer-review(s).pdf
Scientific Misconduct Check 38869-Scientific misconduct check.pdf
Scientific Editor Work List 38869-Scientific editor work list.pdf