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Articles Published Processes
9/25/2018 3:44:36 AM | Browse: 994 | Download: 1578
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Received |
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2018-03-25 08:24 |
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Peer-Review Started |
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2018-03-25 11:40 |
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To Make the First Decision |
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2018-04-11 06:42 |
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Return for Revision |
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2018-04-18 07:10 |
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Revised |
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2018-04-24 01:17 |
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Second Decision |
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2018-05-04 08:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-05-05 23:53 |
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Articles in Press |
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2018-05-05 23:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-09-19 06:31 |
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Publish the Manuscript Online |
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2018-09-25 03:44 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fang Yang and Guo-Xun Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31401510 |
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| Corresponding Author |
Guo-Xun Chen, MD, PhD, Associate Professor, Research Scientist, Department of Nutrition, University of Tennessee at Knoxville, Room 229, Jessie Harris Building, 1215 West Cumberland Avenue, TN, Knoxville 37996, United States. gchen6@utk.edu |
| Key Words |
Autotaxin; Lysophosphatidic acid receptors; Obesity; Lysophosphatidic acid; Insulin resistance; Liver fibrosis |
| Core Tip |
Lysophosphatidic acid (LPA) is mainly derived from hydrolysis of lysophosphatidylcholine, a process mediated by lysophospholipase D activity in proteins such as autotaxin (ATX). The binding of LPA to its receptors LPA1-6 activates multiple cellular signaling pathways and leads to changes. Studies using genetically modified animals have begun to reveal the roles of LPA pathways in metabolic active tissues and organs. The present review summarized recent progresses in the studies of extracellular and intracellular LPA production pathways; the functions, structural and biochemical properties of ATX and LPA receptors. Furthermore, the potential roles of LPA production and LPA receptor signaling pathways in obesity, insulin resistance and liver fibrosis are discussed. |
| Publish Date |
2018-09-25 03:44 |
| Citation |
Yang F, Chen GX. production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis. World J Gastroenterol 2018; 24(36): 4132-4151 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i36/4132.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i36.4132 |
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