Publication Name	World Journal of Gastroenterology
Manuscript ID	3887
Country	China

Received	2013-05-30 15:26
Peer-Review Started	2013-05-31 08:36
To Make the First Decision	2013-07-05 18:40
Return for Revision	2013-07-15 22:34
Revised	2013-09-24 21:24
Second Decision	2013-09-29 12:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-29 22:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-15 19:05
Typeset the Manuscript	2013-12-03 10:27
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor
Manuscript Source	Invited Manuscript
All Author List	Xiu-Jun Li, Yi Luo and Yong-Fen Yi
Funding Agency and Grant Number
Corresponding Author	Dr. Yong-Fen Yi, Department of Pathology, Chongqing Medical University, No. 1, Yixueyuan Road, Chongqing 400016, China. yiyongfen@hotmail.com
Key Words	Gastric cancer; P115; Migration inhibitory factor; Proliferation; Protein interaction
Core Tip	Gastric cancer is one of the most common cancers. P115 is a tether protein which plays a key role in cell proliferation through combination with binding partners, including migration inhibitory factor (MIF). The present study showed that P115 and MIF were specifically expressed in gastric cancer tissues and cells. P115 promoted cell proliferation and G0-G1 to S phase transition. Cell cycle regulators, including cyclin D1, Mcm2, PCNA, pERK1/2 and p53 were up-regulated by P115. P115 interacted with MIF and stimulated the secretion of MIF into the culture supernatant. In summary, P115 promotes proliferation of gastric cancer cells through an interaction with MIF.
Publish Date	2013-12-18 10:00
Citation	Li XJ, Luo Y, Yi YF. P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor. World J Gastroenterol 2013; 19(46): 8619-8629
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8619.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8619

Full Article (PDF)	WJG-19-8619.pdf
Manuscript File	3887-Review.doc
Answering Reviewers	3887-Answering reviewers.pdf
Copyright License Agreement	3887-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3887-Language certificate.PDF
Peer-review Report	3887-Peer review(s).pdf
Scientific Editor Work List	3887-Scientific editor work list.doc