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Articles Published Processes
4/27/2018 3:25:40 AM | Browse: 848 | Download: 997
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Received |
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2018-03-27 09:53 |
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Peer-Review Started |
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2018-03-27 10:47 |
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To Make the First Decision |
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2018-04-03 03:53 |
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Return for Revision |
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2018-04-06 09:21 |
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Revised |
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2018-04-10 08:12 |
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Second Decision |
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2018-04-13 09:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-04-15 23:09 |
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Articles in Press |
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2018-04-15 23:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-04-25 11:13 |
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Publish the Manuscript Online |
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2018-04-27 03:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Min Choi, So-Young Lee and Bum-Joon Kim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Health Technology R&D Project through the Korea Health Industry Development Institute and the Ministry of Health and Welfare |
HI14C0955 |
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| Corresponding Author |
Bum-Joon Kim, PhD, Professor, Department of Biomedical Sciense, Microbiology and Immunology, and Liver Research Institute, Seoul National University, College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul 110799, South Korea. kbumjoon@snu.ac.kr |
| Key Words |
Hepatitis B virus; Polymerase; Reverse transcriptase; Preexisting mutations; Hepatocellular carcinoma |
| Core Tip |
The prevalence of preexisting reverse transcriptase (RT) mutations in treatment-naïve patients largely depends on geographic factors, HBV genotypes, HBeAg serostatus, hepatitis B virus (HBV) viral loads, disease progression, intergenotypic recombination, co-infection with HIV and the method used for detecting the mutation. Genotype-dependent polymorphic amino acid substitutions in RT may affect the emergence of drug resistance, and genotype C exhibits relatively elevated spontaneous RT mutation rates. HBeAg-negative status and low viral loads are significantly associated with a higher frequency and prevalence of HBV preexisting RT mutations. Preexisting mutations are most frequently found in the A-B interdomain of RT, mutations of which can lead to simultaneous viral immune escape. |
| Publish Date |
2018-04-27 03:25 |
| Citation |
Choi YM, Lee SY, Kim BJ. Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. World J Gastroenterol 2018; 24(16): 1708-1724 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i16/1708.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i16.1708 |
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