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6/4/2018 7:22:04 AM | Browse: 1081 | Download: 1247
Publication Name World Journal of Gastroenterology
Manuscript ID 39040
Country/Territory Japan
Received
2018-03-28 06:02
Peer-Review Started
2018-03-28 11:26
To Make the First Decision
2018-04-19 01:32
Return for Revision
2018-04-21 09:28
Revised
2018-04-24 08:15
Second Decision
2018-04-25 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-26 02:15
Articles in Press
2018-04-26 02:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-05-17 17:47
Typeset the Manuscript
2018-06-01 04:09
Publish the Manuscript Online
2018-06-04 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA
Manuscript Source Invited Manuscript
All Author List Kazuma Sekiba, Motoyuki Otsuka, Motoko Ohno, Mari Yamagami, Takahiro Kishikawa, Tatsunori Suzuki, Rei Ishibashi, Takahiro Seimiya, Eri Tanaka and Kazuhiko Koike
ORCID
Author(s) ORCID Number
Kazuma Sekiba http://orcid.org/0000-0002-9429-1974
Motoyuki Otsuka http://orcid.org/0000-0003-2869-2881
Motoko Ohno http://orcid.org/0000-0002-3437-3468
Mari Yamagami http://orcid.org/0000-0002-1533-8245
Takahiro Kishikawa http://orcid.org/0000-0002-8602-5916
Tatsunori Suzuki http://orcid.org/0000-0002-2344-7732
Rei Ishibashi http://orcid.org/0000-0002-9649-6471
Takahiro Seimiya http://orcid.org/0000-0003-1698-030
Eri Tanaka http://orcid.org/0000-0001-5823-0472
Kazuhiko Koike http://orcid.org/0000-0002-9739-9243
Funding Agency and Grant Number
Funding Agency Grant Number
Research Program on Hepatitis from Japan Agency for Medical Research and Development, AMED JP18fk0210214
Project for Cancer Research and Therapeutic Evolution (P-CREATE) from AMED JP19cm0106602
Corresponding Author Motoyuki Otsuka, MD, Doctor, Lecturer, Department of Gastroenterology, The University of Tokyo, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Tokyo 113-8655, Tokyo, Japan. otsukamo-tky@umin.ac.jp
Key Words Hepatitis B virus; Hepatitis B virus RNA; MicroRNA; Smc5/6; Viral replication; Hepatic fibrosis; Genome integration; Hepatocellular carcinoma
Core Tip Recently, it has been shown that hepatitis B virus (HBV) RNAs have diverse biological functions in the pathogenesis of HBV. HBV RNAs may work as sponges for host miRNAs and deregulate miRNA functions. Novel viral-host fusion RNA may be produced from HBV-DNA integration sites, which may also have pathological functions. Understanding HBV RNA transcription and the biological functions of HBV-related RNAs may open a new avenue for the development of novel HBV therapeutics that target HBV RNAs.
Publish Date 2018-06-04 07:22
Citation Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA. World J Gastroenterol 2018; 24(21): 2261-2268
URL http://www.wjgnet.com/1007-9327/full/v24/i21/2261.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i21.2261
Full Article (PDF) WJG-24-2261.pdf
Full Article (Word) WJG-24-2261.doc
Manuscript File 39040-Review.docx
Answering Reviewers 39040-Answering reviewers.pdf
Audio Core Tip 39040-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39040-Conflict-of-interest statement.pdf
Copyright License Agreement 39040-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 39040-Language certificate.pdf
Peer-review Report 39040-Peer-review(s).pdf
Scientific Misconduct Check 39040-Scientific misconduct check.pdf
Scientific Editor Work List 39040-Scientific editor work list.pdf