| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kazuma Sekiba, Motoyuki Otsuka, Motoko Ohno, Mari Yamagami, Takahiro Kishikawa, Tatsunori Suzuki, Rei Ishibashi, Takahiro Seimiya, Eri Tanaka and Kazuhiko Koike |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Program on Hepatitis from Japan Agency for Medical Research and Development, AMED |
JP18fk0210214 |
| Project for Cancer Research and Therapeutic Evolution (P-CREATE) from AMED |
JP19cm0106602 |
|
| Corresponding Author |
Motoyuki Otsuka, MD, Doctor, Doctor, Lecturer, Department of Gastroenterology, The University of Tokyo, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Tokyo 113-8655, Tokyo, Japan. otsukamo-tky@umin.ac.jp |
| Key Words |
Hepatitis B virus; Hepatitis B virus RNA; MicroRNA; Smc5/6; Viral replication; Hepatic fibrosis; Genome integration; Hepatocellular carcinoma |
| Core Tip |
Recently, it has been shown that hepatitis B virus (HBV) RNAs have diverse biological functions in the pathogenesis of HBV. HBV RNAs may work as sponges for host miRNAs and deregulate miRNA functions. Novel viral-host fusion RNA may be produced from HBV-DNA integration sites, which may also have pathological functions. Understanding HBV RNA transcription and the biological functions of HBV-related RNAs may open a new avenue for the development of novel HBV therapeutics that target HBV RNAs. |
| Publish Date |
2018-06-04 07:22 |
| Citation |
Sekiba K, Otsuka M, Ohno M, Yamagami M, Kishikawa T, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K. Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA. World J Gastroenterol 2018; 24(21): 2261-2268 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i21/2261.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i21.2261 |
