Publication Name	World Journal of Anesthesiology
Manuscript ID	39078
Country	United States

Received	2018-03-28 00:26
Peer-Review Started	2018-03-28 15:27
To Make the First Decision	2018-05-02 03:42
Return for Revision	2018-05-03 06:42
Revised	2018-05-28 01:01
Second Decision	2018-06-01 07:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-02 17:08
Articles in Press	2018-06-02 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-07 00:18
Publish the Manuscript Online	2018-06-07 07:44

ISSN	2218-6182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://www.creativecommons.org/licenses/by-nc/4.0/
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Category	Anesthesiology
Manuscript Type	Review
Article Title	Targeting tumor necrosis factor in the brain relieves neuropathic pain
Manuscript Source	Invited Manuscript
All Author List	Tracey A Ignatowski and Robert N Spengler
ORCID	Author(s) ORCID Number Tracey A Ignatowski http://orcid.org/0000-0002-8033-4566 Robert N Spengler http://orcid.org/0000-0001-7107-4013
Funding Agency and Grant Number
Corresponding Author	Tracey A Ignatowski, PhD, Assistant Professor, Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, United States. tai1@buffalo.edu
Key Words	Neuropathic pain; Tumor necrosis factor; Brain; Norepinephrine; Analgesia
Core Tip	Chronic pain is a widespread health problem. Current treatments, including opioids or non-steroidal anti-inflammatory drugs are inadequate as they lack sufficient efficacy, produce numerous side effects and hold the potential for addiction. Preclinical studies show that elevated brain tumor necrosis factor (TNF) levels during chronic pain are a novel target for producing analgesia. TNF can be practically targeted by non-invasive delivery of anti-TNF biologics directly to the ventricles of the brain via a peripheral perispinal injection. Herein we discuss decreasing TNF activity in the brain as a treatment to provide a superior analgesic strategy. Animal study results indicate potential benefit for patients with treatment-resistant pain.
Publish Date	2018-06-07 07:44
Citation	Ignatowski TA, Spengler RN. Targeting tumor necrosis factor in the brain relieves neuropathic pain. World J Anesthesiol 2018; 7(2): 10-19
URL	http://www.wjgnet.com/2218-6182/full/v7/i2/10.htm
DOI	http://dx.doi.org/10.5313/wja.v7.i2.10

Full Article (PDF)	WJA-7-10.pdf
Full Article (Word)	WJA-7-10.doc
Manuscript File	39078-Review.docx
Answering Reviewers	39078-Answering reviewers.pdf
Audio Core Tip	39078-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	39078-Conflict-of-interest statement.pdf
Copyright License Agreement	39078-Copyright assignment.pdf
Peer-review Report	39078-Peer-review(s).pdf
Scientific Misconduct Check	39078-Scientific misconduct check.pdf
Scientific Editor Work List	39078-Scientific editor work list.pdf