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6/7/2018 7:44:21 AM | Browse: 360 | Download: 155
Publication Name World Journal of Anesthesiology
Manuscript ID 39078
Country/Territory United States
2018-03-28 00:26
Peer-Review Started
2018-03-28 15:27
To Make the First Decision
2018-05-02 03:42
Return for Revision
2018-05-03 06:42
2018-05-28 01:01
Second Decision
2018-06-01 07:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-02 17:08
Articles in Press
2018-06-02 17:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-06-07 00:18
Publish the Manuscript Online
2018-06-07 07:44
ISSN 2218-6182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://www.creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Review
Article Title Targeting tumor necrosis factor in the brain relieves neuropathic pain
Manuscript Source Invited Manuscript
All Author List Tracey A Ignatowski and Robert N Spengler
Author(s) ORCID Number
Tracey A Ignatowski http://orcid.org/0000-0002-8033-4566
Robert N Spengler http://orcid.org/0000-0001-7107-4013
Funding Agency and Grant Number
Corresponding author Tracey A Ignatowski, PhD, Assistant Professor, Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, 955 Main Street, Buffalo, NY 14203, United States. tai1@buffalo.edu
Key Words Neuropathic pain; Tumor necrosis factor; Brain; Norepinephrine; Analgesia
Core Tip Chronic pain is a widespread health problem. Current treatments, including opioids or non-steroidal anti-inflammatory drugs are inadequate as they lack sufficient efficacy, produce numerous side effects and hold the potential for addiction. Preclinical studies show that elevated brain tumor necrosis factor (TNF) levels during chronic pain are a novel target for producing analgesia. TNF can be practically targeted by non-invasive delivery of anti-TNF biologics directly to the ventricles of the brain via a peripheral perispinal injection. Herein we discuss decreasing TNF activity in the brain as a treatment to provide a superior analgesic strategy. Animal study results indicate potential benefit for patients with treatment-resistant pain.
Publish Date 2018-06-07 07:44
Citation Ignatowski TA, Spengler RN. Targeting tumor necrosis factor in the brain relieves neuropathic pain. World J Anesthesiol 2018; 7(2): 10-19
Url http://www.wjgnet.com/2218-6182/full/v7/i2/10.htm
DOI http://dx.doi.org/10.5313/wja.v7.i2.10
Full Article (PDF) WJA-7-10.pdf
Full Article (Word) WJA-7-10.doc
Manuscript File 39078-Review.docx
Answering Reviewers 39078-Answering reviewers.pdf
Audio Core Tip 39078-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39078-Conflict-of-interest statement.pdf
Copyright License Agreement 39078-Copyright assignment.pdf
Peer-review Report 39078-Peer-review(s).pdf
Scientific Misconduct Check 39078-Scientific misconduct check.pdf
Scientific Editor Work List 39078-Scientific editor work list.pdf