Publication Name	World Journal of Gastroenterology
Manuscript ID	39183
Country	Chile

Received	2018-04-10 02:06
Peer-Review Started	2018-04-10 07:31
To Make the First Decision	2018-04-27 02:02
Return for Revision	2018-04-27 06:51
Revised	2018-05-17 12:49
Second Decision	2018-06-26 09:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-27 04:19
Articles in Press	2018-06-27 04:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-07-25 03:12
Publish the Manuscript Online	2018-07-27 06:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Manuscript Source	Invited Manuscript
All Author List	Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela and Andrew FG Quest
ORCID	Author(s) ORCID Number Denisse Bravo http://orcid.org/0000-0002-5749-4086 Anilei Hoare http://orcid.org/0000-0002-1617-6401 Cristopher Soto http://orcid.org/0000-0002-8286-5512 Manuel A Valenzuela http://orcid.org/0000-0002-8833-7382 Andrew FG Quest http://orcid.org/0000-0001-8755-1590
Funding Agency and Grant Number	Funding Agency Grant Number Fondo Nacional de Desarrollo Científico y Tecnológico 1171615 (to Valenzuela MA) Comisión Nacional de Investigación Científica y Tecnológica-Fondos de Financiamiento de Centros de Investigación en Áreas Prioritarias 15130011 (to Quest AF) Fondo Nacional de Desarrollo Científico y Tecnológico 1170925 (to Quest AF) Fondo para la Investigación en Odontología Universidad de Chile 17/020 (to Bravo D)
Corresponding Author	Andrew FG Quest, PhD, Professor, Advanced Center for Chronic Diseases, Center for Studies on Exercise, Metabolism and Cancer, Biomedical Science Institute, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380447, Chile. aquest@med.uchile.cl
Key Words	Helicobacter pylori; Co-evolution; Extra-gastric diseases; Inflammation; Microbiome
Core Tip	This review focuses on discussing how Helicobacter pylori (H. pylori) has co-evolved with humans, potential mechanisms that may explain both positive and negative correlations in population-based studies between H. pylori infection and the development of several diseases, as well as how inflammation and/or changes in the microbiome might be linked to the respective outcomes. Our analysis of the literature reveals that human infection by H. pylori has a longstanding history, whereby the consequences therefore are ex­tremely complex and not always detrimental to the human host. Thus, future research should focus on determining how potentially beneficial consequences of this interaction could be promoted all the while preventing the disease-causing effects in humans.
Publish Date	2018-07-27 06:43
Citation	Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol 2018; 24(28): 3071-3089
URL	http://www.wjgnet.com/1007-9327/full/v24/i28/3071.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i28.3071

Full Article (PDF)	WJG-24-3071.pdf
Manuscript File	39183-Review.docx
Answering Reviewers	39183-Answering reviewers.pdf
Audio Core Tip	39183-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	39183-Conflict-of-interest statement.pdf
Copyright License Agreement	39183-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39183-Grant application form(s).pdf
Peer-review Report	39183-Peer-review(s).pdf
Scientific Misconduct Check	39183-Scientific misconduct check.pdf
Scientific Editor Work List	39183-Scientific editor work list.pdf