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Articles Published Processes
8/13/2018 7:45:11 AM | Browse: 1009 | Download: 1322
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Received |
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2018-04-10 02:17 |
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Peer-Review Started |
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2018-04-10 07:12 |
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First Decision by Editorial Office Director |
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2018-05-09 01:27 |
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Return for Revision |
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2018-05-16 09:48 |
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Revised |
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2018-05-29 17:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-06-25 09:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-06-25 19:16 |
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Articles in Press |
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2018-06-25 19:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-08-08 03:07 |
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Publish the Manuscript Online |
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2018-08-13 07:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Izzet Mehmet Akcay, Seyma Katrinli, Kamil Ozdil, Gizem Dinler Doganay and Levent Doganay |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Levent Doganay, MD, Associate Professor, Doctor, Doctor, Department of Gastroenterology and Hepatology, Umraniye Teaching and Research Hospital, Umraniye, Istanbul 34764, Türkiye. levent.doganay@saglik.gov.tr |
| Key Words |
Genome-wide association studies; Hepatitis B infection; Hepatocellular carcinoma; Cirrhosis; Antigen presentation; Immune response to hepatitis B virus |
| Core Tip |
Genome-wide association studies (GWAS) have proven to be very useful in uncovering the host genetic factors that influence the clinical outcomes of hepatitis B virus (HBV) infection. Both class Ⅰ and class Ⅱ human leukocyte antigen (HLA) genes were implicated in persistence of HBV infection; associated variants affected antigen-binding specificities and expression levels of HLA molecules. HBV persistence and vaccine nonresponse were associated with the same HLA-DP allotypes, suggesting a critical role for the surface antigen in HBV pathogenesis. These findings might be exploited for development of potent vaccines based on alternative epitopes. GWAS for HBV-related pathologies identified many other immune-related genes, and provided genetic markers to detect the individuals at high risk for HBV-related diseases. |
| Publish Date |
2018-08-13 07:45 |
| Citation |
Akcay IM, Katrinli S, Ozdil K, Dinler Doganay G, Doganay L. Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies. World J Gastroenterol 2018; 24(30): 3347-3360 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i30/3347.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i30.3347 |
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