Publication Name	World Journal of Gastroenterology
Manuscript ID	39217
Country	China

Received	2018-04-09 06:33
Peer-Review Started	2018-04-09 11:42
To Make the First Decision	2018-05-09 04:08
Return for Revision	2018-05-16 09:58
Revised	2018-05-22 07:01
Second Decision	2018-06-25 08:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-25 19:15
Articles in Press	2018-06-25 19:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-04 16:32
Typeset the Manuscript	2018-07-25 03:15
Publish the Manuscript Online	2018-07-27 06:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Basic Study
Article Title	Moxibustion treatment modulates the gut microbiota and immune function in a dextran sulphate sodium-induced colitis rat model
Manuscript Source	Unsolicited Manuscript
All Author List	Qin Qi, Ya-Nan Liu, Xiao-Ming Jin, Lin-Shuang Zhang, Cun Wang, Chun-Hui Bao, Hui-Rong Liu, Huan-Gan Wu and Xiao-Mei Wang
ORCID	Author(s) ORCID Number Qin Qi http://orcid.org/0000-0002-0563-1560 Ya-Nan Liu http://orcid.org/0000-2572-7930-5364 Xiao-Ming Jin http://orcid.org/0000-1234-2436-6523 Lin-Shuang Zhang http://orcid.org/0000-0003-4043-8528 Cun Wang http://orcid.org/0000-5657-0909-6832 Chun-Hui Bao http://orcid.org/0000-3234-1282-0219 Hui-Rong Liu http://orcid.org/0000-0002-9697-5085 Huan-Gan Wu http://orcid.org/0000-0003-0563-1560 Xiao-Mei Wang http://orcid.org/0000-0003-1962-0827
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81473758 National Basic Research Programme of China (973 Programme) 2015CB554500
Corresponding Author	Xiao-Mei Wang, MD, PhD, Associate Professor, Shanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, 650 South Wanping Road, Xuhui District, Shanghai 200030, China. wxm123@vip.sina.com
Key Words	Ulcerative colitis; Moxibustion; 16S rRNA; Gut microbiome; Inflammatory cytokine
Core Tip	Ulcerative colitis (UC) is a form of inflammatory bowel disease and microbial dysbiosis is an important pathological factor of UC. Moxibustion treatment can repair mucosal tissue damage and regulate immune function in patients with UC associated with gut microbiome changes. In this study, moxibustion can significantly reduce the colonic tissue damage and the levels of pro-inflammatory cytokines and anti-inflammatory cytokines in rats with 4% dextran sulphate sodium-induced ulcerative colitis, relieve intestinal inflammation, and promote the restoration of impaired colonic tissue. In addition, moxibustion can in­crease the diversity of the gut microbiome and the UC with 7 d of moxibustion had a higher alpha diversity than UC with 14 d of moxibustion.
Publish Date	2018-07-27 06:43
Citation	Qi Q, Liu YN, Jin XM, Zhang LS, Wang C, Bao CH, Liu HR, Wu HG, Wang XM. Moxibustion treatment modulates the gut microbiota and immune function in a dextran sulphate sodium-induced colitis rat model. World J Gastroenterol 2018; 24(28): 3130-3144
URL	http://www.wjgnet.com/1007-9327/full/v24/i28/3130.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i28.3130

Full Article (PDF)	WJG-24-3130.pdf
The ARRIVE Guidelines	39217-The ARRIVE Guidelines.pdf
Manuscript File	39217-Review.docx
Answering Reviewers	39217-Answering reviewers.pdf
Audio Core Tip	39217-Audio core tip.mp3
Biostatistics Review Certificate	39217-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39217-Conflict-of-interest statement.pdf
Copyright License Agreement	39217-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39217-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	39217-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	39217-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	39217-Language certificate.pdf
Supplementary Material	39217-Supplementary material.pdf
Peer-review Report	39217-Peer-review(s).pdf
Scientific Misconduct Check	39217-Scientific misconduct check.pdf
Scientific Editor Work List	39217-Scientific editor work list.pdf