Publication Name	World Journal of Cardiology
Manuscript ID	39241
Country	United States

Received	2018-04-06 05:54
Peer-Review Started	2018-04-07 07:01
To Make the First Decision	2018-06-06 07:26
Return for Revision	2018-06-08 00:42
Revised	2018-07-05 18:32
Second Decision	2018-07-13 09:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-07-16 05:42
Articles in Press	2018-07-16 05:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-26 00:43
Typeset the Manuscript	2018-09-29 01:42
Publish the Manuscript Online	2018-09-30 06:52

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo
Manuscript Source	Invited Manuscript
All Author List	Kanimozhi Vairamani, Vikram Prasad, Yigang Wang, Wei Huang, Yinhuai Chen, Mario Medvedovic, John N Lorenz and Gary E Shull
ORCID	Author(s) ORCID Number Kanimozhi Vairamani http://orcid.org/0000-0002-1596-7762 Vikram Prasad http://orcid.org/0000-0002-8852-3986 Yigang Wang http://orcid.org/0000-0002-0872-1860 Wei Huang http://orcid.org/0000-0003-3046-4220 Yinhuai Chen http://orcid.org/0000-0002-7954-8452 Mario Medvedovic http://orcid.org/0000-0003-4510-3102 John N Lorenz http://orcid.org/0000-0003-2161-9833 Gary E Shull http://orcid.org/0000-0002-1719-234X
Funding Agency and Grant Number	Funding Agency Grant Number NIH HL061974 (to Gary E Shull) NIH R01HL136025 (to Yigang Wang) NIH P30ES006096 (to Mario Medvedovic) Center for Clinical and Translational Science and Training, University of Cincinnati to Gary E Shull Research Innovation Seed Grant from the University of Cincinnati to Gary E Shull and John N Lorenz
Corresponding Author	Gary E Shull, PhD, Professor, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, United States. shullge@ucmail.uc.edu
Key Words	Deep sequencing; Ischemic; Apoptosis; Slc4a4; NBCe1
Core Tip	The NBCe1 Na+-HCO3- cotransporter and NHE1 Na+/H+ exchanger both mediate Na+-loading and intracellular pH regulation in cardiomyocytes. Inhibition of NHE1 protects against ischemia-reperfusion (IR) injury, and evidence suggests that loss of NBCe1 activity could also be cardioprotective. We have developed a conditional NBCe1 knockout mouse model and have used it to determine the effects of NBCe1 ablation in cardiac muscle. These studies demonstrate that loss of NBCe1 does not impair cardiac performance. However, cardiomyocyte apoptosis following IR injury in vivo is much lower in hearts that lack NBCe1, thus indicating that loss of NBCe1 is cardioprotective.
Publish Date	2018-09-30 06:52
Citation	Vairamani K, Prasad V, Wang Y, Huang W, Chen Y, Medvedovic M, Lorenz JN, Shull GE. NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo. World J Cardiol 2018; 10(9): 97-109
URL	http://www.wjgnet.com/1949-8462/full/v10/i9/97.htm
DOI	http://dx.doi.org/10.4330/wjc.v10.i9.97

Full Article (PDF)	WJC-10-97.pdf
Full Article (Word)	WJC-10-97.doc
The ARRIVE Guidelines	39241-The ARRIVE Guidelines.pdf
Manuscript File	39241-Review.docx
Answering Reviewers	39241-Answering reviewers.pdf
Audio Core Tip	39241-Audio core tip.mp3
Biostatistics Review Certificate	39241-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39241-Conflict-of-interest statement.pdf
Copyright License Agreement	39241-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39241-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	39241-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	39241-Institutional review board statement.pdf
Peer-review Report	39241-Peer-review(s).pdf
Scientific Misconduct Check	39241-Scientific misconduct check.pdf
Scientific Editor Work List	39241-Scientific editor work list.pdf