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Publication Name World Journal of Cardiology
Manuscript ID 39241
Country/Territory United States
Received
2018-04-06 05:54
Peer-Review Started
2018-04-07 07:01
To Make the First Decision
2018-06-06 07:26
Return for Revision
2018-06-08 00:42
Revised
2018-07-05 18:32
Second Decision
2018-07-13 09:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-07-16 05:42
Articles in Press
2018-07-16 05:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-26 00:43
Typeset the Manuscript
2018-09-29 01:42
Publish the Manuscript Online
2018-09-30 06:52
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo
Manuscript Source Invited Manuscript
All Author List Kanimozhi Vairamani, Vikram Prasad, Yigang Wang, Wei Huang, Yinhuai Chen, Mario Medvedovic, John N Lorenz and Gary E Shull
ORCID
Author(s) ORCID Number
Kanimozhi Vairamani http://orcid.org/0000-0002-1596-7762
Vikram Prasad http://orcid.org/0000-0002-8852-3986
Yigang Wang http://orcid.org/0000-0002-0872-1860
Wei Huang http://orcid.org/0000-0003-3046-4220
Yinhuai Chen http://orcid.org/0000-0002-7954-8452
Mario Medvedovic http://orcid.org/0000-0003-4510-3102
John N Lorenz http://orcid.org/0000-0003-2161-9833
Gary E Shull http://orcid.org/0000-0002-1719-234X
Funding Agency and Grant Number
Funding Agency Grant Number
NIH HL061974 (to Gary E Shull)
NIH R01HL136025 (to Yigang Wang)
NIH P30ES006096 (to Mario Medvedovic)
Center for Clinical and Translational Science and Training, University of Cincinnati to Gary E Shull
Research Innovation Seed Grant from the University of Cincinnati to Gary E Shull and John N Lorenz
Corresponding Author Gary E Shull, PhD, Professor, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, United States. shullge@ucmail.uc.edu
Key Words Deep sequencing; Ischemic; Apoptosis; Slc4a4; NBCe1
Core Tip The NBCe1 Na+-HCO3- cotransporter and NHE1 Na+/H+ exchanger both mediate Na+-loading and intracellular pH regulation in cardiomyocytes. Inhibition of NHE1 protects against ischemia-reperfusion (IR) injury, and evidence suggests that loss of NBCe1 activity could also be cardioprotective. We have developed a conditional NBCe1 knockout mouse model and have used it to determine the effects of NBCe1 ablation in cardiac muscle. These studies demonstrate that loss of NBCe1 does not impair cardiac performance. However, cardiomyocyte apoptosis following IR injury in vivo is much lower in hearts that lack NBCe1, thus indicating that loss of NBCe1 is cardioprotective.
Publish Date 2018-09-30 06:52
Citation Vairamani K, Prasad V, Wang Y, Huang W, Chen Y, Medvedovic M, Lorenz JN, Shull GE. NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo. World J Cardiol 2018; 10(9): 97-109
URL http://www.wjgnet.com/1949-8462/full/v10/i9/97.htm
DOI http://dx.doi.org/10.4330/wjc.v10.i9.97
Full Article (PDF) WJC-10-97.pdf
Full Article (Word) WJC-10-97.doc
The ARRIVE Guidelines 39241-The ARRIVE Guidelines.pdf
Manuscript File 39241-Review.docx
Answering Reviewers 39241-Answering reviewers.pdf
Audio Core Tip 39241-Audio core tip.mp3
Biostatistics Review Certificate 39241-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39241-Conflict-of-interest statement.pdf
Copyright License Agreement 39241-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39241-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 39241-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 39241-Institutional review board statement.pdf
Peer-review Report 39241-Peer-review(s).pdf
Scientific Misconduct Check 39241-Scientific misconduct check.pdf
Scientific Editor Work List 39241-Scientific editor work list.pdf