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Articles Published Processes
9/27/2018 9:38:46 AM | Browse: 1127 | Download: 1455
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Received |
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2018-04-28 01:06 |
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Peer-Review Started |
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2018-05-03 01:58 |
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To Make the First Decision |
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2018-05-24 23:53 |
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Return for Revision |
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2018-05-25 07:45 |
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Revised |
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2018-07-20 23:03 |
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Second Decision |
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2018-08-28 10:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-08-28 15:57 |
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Articles in Press |
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2018-08-28 15:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-09-26 00:20 |
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Publish the Manuscript Online |
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2018-09-27 09:38 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mitchell S Cappell, Ismail Hader and Mitual Amin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mitchell S Cappell, FACG, MD, PhD, Attending Doctor, Chief Doctor, Professor, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 W. Thirteen Mile Rd., Royal Oak, MI 48073, United States. mitchell.cappell@beaumont.edu |
| Key Words |
Hemophagocytic lymphohistiocytosis; Acute liver failure; Liver injury; Liver transplantation; Acquired immune hyperactivation; Pancytopenia |
| Core Tip |
This work systematically reviews liver disease in hemophagocytic lymphohistiocytosis (HLH), proposes contraindications for liver-transplantation in such patients, and reports an illustrative case. A 47-year-old-man was hospitalized with high-grade pyrexia, total-bilirubin = 45 g/dL, and profound neutropenia. Bone marrow biopsy/aspirate revealed hemophagocytic histiocytes. The patient had HLH, satisfying 6 Histiocytic Society criteria. Liver-biopsy histopathology revealed relatively well-preserved hepatic parenchyma, except for sparse hepatocytic necrosis. The patient was not a liver-transplant-candidate, despite model for end stage liver disease-score = 33, due to multi-organ failure from HLH. He expired from multi-organ failure despite receiving corticosteroids. This case and systematic review reveals patients with HLH may not be liver transplant candidates because of liver failure from multisystem failure. |
| Publish Date |
2018-09-27 09:38 |
| Citation |
Cappell MS, Hader I, Amin M. Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review. World J Hepatol 2018; 10(9): 629-636 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i9/629.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i9.629 |
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