Publication Name	World Journal of Hepatology
Manuscript ID	39591
Country	United States

Received	2018-04-28 01:06
Peer-Review Started	2018-05-03 01:58
First Decision by Editorial Office Director	2018-05-24 22:59
Return for Revision	2018-05-25 07:45
Revised	2018-07-20 23:03
Publication Fee Transferred
Second Decision by Editor	2018-08-28 10:24
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-08-28 15:57
Articles in Press	2018-08-28 15:57
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-26 00:20
Publish the Manuscript Online	2018-09-27 09:38

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review
Manuscript Source	Invited Manuscript
All Author List	Mitchell S Cappell, Ismail Hader and Mitual Amin
ORCID	Author(s) ORCID Number Mitchell S Cappell http://orcid.org/0000-0003-3445-5428 Ismail Hader http://orcid.org/0000-0002-8080-0416 Mitual Amin http://orcid.org/0000-0002-0558-2615
Funding Agency and Grant Number
Corresponding Author	Mitchell S Cappell, FACG, MD, PhD, Attending Doctor, Chief Doctor, Professor, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 W. Thirteen Mile Rd., Royal Oak, MI 48073, United States. mitchell.cappell@beaumont.edu
Key Words	Hemophagocytic lymphohistiocytosis; Acute liver failure; Liver injury; Liver transplantation; Acquired immune hyperactivation; Pancytopenia
Core Tip	This work systematically reviews liver disease in hemophagocytic lymphohistiocytosis (HLH), proposes contraindications for liver-transplantation in such pati­ents, and reports an illustrative case. A 47-year-old-man was hospitalized with high-grade pyrexia, total-bilirubin = 45 g/dL, and profound neutropenia. Bone marrow biopsy/aspirate revealed hemophagocytic his­tiocytes. The patient had HLH, satisfying 6 Histiocytic Society criteria. Liver-biopsy histopathology revealed relatively well-preserved hepatic parenchyma, except for sparse hepatocytic necrosis. The patient was not a liver-transplant-candidate, despite model for end stage liver disease-score = 33, due to multi-organ failure from HLH. He expired from multi-organ failure despite receiving corticosteroids. This case and systematic review reveals patients with HLH may not be liver tra­nsplant candidates because of liver failure from mul­tisystem failure.
Publish Date	2018-09-27 09:38
Citation	Cappell MS, Hader I, Amin M. Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymp­hohistiocytosis: Case report and systematic literature review. World J Hepatol 2018; 10(9): 629-636
URL	http://www.wjgnet.com/1948-5182/full/v10/i9/629.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i9.629

Full Article (PDF)	WJH-10-629.pdf
Full Article (Word)	WJH-10-629.doc
PRISMA 2009 Checklist	39591-PRISMA 2009 Checklist.pdf
Manuscript File	39591-Review.docx
Answering Reviewers	39591-Answering reviewers.pdf
Audio Core Tip	39591-Audio core tip.mp3
Biostatistics Review Certificate	39591-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39591-Conflict-of-interest statement.pdf
Copyright License Agreement	39591-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	39591-Non-Native-Speakers-of-English-Editing-Certificate-revision.docx
Supplementary Material	39591-Supplementary-Material-revision_0116.docx
Peer-review Report	39591-Peer-review(s).pdf
Scientific Misconduct Check	39591-Scientific misconduct check.pdf
Scientific Editor Work List	39591-Scientific editor work list.pdf