Publication Name	World Journal of Gastroenterology
Manuscript ID	39634
Country	Spain

Received	2018-05-03 10:32
Peer-Review Started	2018-05-04 06:47
To Make the First Decision	2018-05-17 02:55
Return for Revision	2018-05-21 07:51
Revised	2018-06-28 19:13
Second Decision	2018-07-13 09:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-07-16 01:50
Articles in Press	2018-07-16 01:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-31 09:11
Publish the Manuscript Online	2018-09-06 01:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Javier A García-Vilas and Miguel Ángel Medina
ORCID	Author(s) ORCID Number Javier A García-Vilas http://orcid.org/0000-0003-0700-5069 Miguel Ángel Medina http://orcid.org/0000-0001-7275-6462
Funding Agency and Grant Number	Funding Agency Grant Number MINECO and FEDER BIO2014-56092-R Andalusian Government and FEDER P12-CTS-1507 Andalusian Government BIO-267
Corresponding Author	Miguel Ángel Medina, PhD, Full Professor, Department of Molecular Biology and Biochemistry, University of Málaga, Department of Molecular Biology and Biochemistry Faculty of Sciences, University of Malaga , Boulevar Louis Pasteur 31, Málaga 29071, Spain. medina@uma.es
Key Words	Hepatocellular carcinoma; Hepatocyte growth factor/c-MET; Tumor microenvironment; c-Met canonical and non-canonical pathways
Core Tip	Hepatocellular carcinoma (HCC) is a tumor usually arising from previous hepatic diseases as cirrhosis and chronic hepatitis B and C infections. Several studies have shown that a key factor for HCC oncogenesis is chronic inflammation. Inflammation induces changes in the gene expression pattern in surrounding cells. These changes provide an environment with a high level of cytokines, promoting hepatocyte transforma­tion to tumor cells. New therapies against HCC are focused on regulating stromal cells within the tumor microenvironment to avoid HCC progression.
Publish Date	2018-09-06 01:33
Citation	García-Vilas JA, Medina MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications. World J Gastroenterol 2018; 24(33): 3695-3708
URL	http://www.wjgnet.com/1007-9327/full/v24/i33/3695.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i33.3695

Full Article (PDF)	WJG-24-3695.pdf
Full Article (Word)	WJG-24-3695.doc
Manuscript File	39634-Review.doc
Answering Reviewers	39634-Answering reviewers.pdf
Audio Core Tip	39634-Audio core tip.wav
Conflict-of-Interest Disclosure Form	39634-Conflict-of-interest statement.pdf
Copyright License Agreement	39634-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	39634-Language certificate.pdf
Peer-review Report	39634-Peer-review(s).pdf
Scientific Misconduct Check	39634-Scientific misconduct check.pdf
Scientific Editor Work List	39634-Scientific editor work list.pdf