| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
María Dolores Pizarro, María Eugenia Mamprin, Lucas Damián Daurelio, Joaquín Valentín Rodriguez and María Gabriela Mediavilla |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Universidad Nacional de Rosario (UNR), BIO 272, Resol. C.S. |
677/2013 |
| Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), PICT-03-14492, BID 1728 OC/AR (Argentina) |
|
| Regione Autonoma Friuli-Venezia Giulia, Italy |
|
|
| Corresponding Author |
María Gabriela Mediavilla, PhD, Academic Research, Doctor, Doctor, Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Consejo Nacional de Investigaciones Científicas y Tecnológicas, y Universidad Nacional de Rosario, Suipacha 531, Rosario S2002 LRK, Argentina. mediavilla@ibr-conicet.gov.ar |
| Key Words |
Bio-artificial liver; Ammonia detoxification; Device design; Ornithine Transcarbamylase; Rat liver microorgans; Carbamyl Phosphate Synthetase Ⅰ |
| Core Tip |
This work describes the adaptation of a simplified bio-artificial liver (BAL) prototype to make it suitable to house rat liver microorgans (LMOs) as a biological component, and the evaluation of the performance in this new model. We demonstrate that the modification in the design of the artificial parts employed allows a good performance of LMOs, thus showing the importance of architecture and model configuration on the design of these devices. Besides its application as BAL, this mini bioreactor could serve as a suitable laboratory tool to evaluate the behavior and functionality of LMOs subjected to different incubation conditions due to its simple design and the utilization of standard materials. |
| Publish Date |
2018-10-27 04:40 |
| Citation |
Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i10/719.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i10.719 |
