Publication Name	World Journal of Hepatology
Manuscript ID	39857
Country	Argentina

Received	2018-05-22 01:16
Peer-Review Started	2018-05-23 00:29
To Make the First Decision	2018-06-15 02:30
Return for Revision	2018-06-19 01:18
Revised	2018-07-12 15:58
Second Decision	2018-08-06 09:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-07 05:33
Articles in Press	2018-08-07 05:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-08-14 22:52
Typeset the Manuscript	2018-10-22 03:34
Publish the Manuscript Online	2018-10-27 04:40

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance
Manuscript Source	Invited Manuscript
All Author List	María Dolores Pizarro, María Eugenia Mamprin, Lucas Damián Daurelio, Joaquín Valentín Rodriguez and María Gabriela Mediavilla
ORCID	Author(s) ORCID Number María Dolores Pizarro http://orcid.org/0000-0003-3551-2797 María Eugenia Mamprin http://orcid.org/0000-0003-4477-9645 Lucas Damián Daurelio http://orcid.org/0000-0002-1156-2266 Joaquín Valentín Rodriguez http://orcid.org/0000-0002-5552-8211 María Gabriela Mediavilla http://orcid.org/0000-0002-1999-7707
Funding Agency and Grant Number	Funding Agency Grant Number Universidad Nacional de Rosario (UNR), BIO 272, Resol. C.S. 677/2013 Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), PICT-03-14492, BID 1728 OC/AR (Argentina) Regione Autonoma Friuli-Venezia Giulia, Italy
Corresponding Author	María Gabriela Mediavilla, PhD, Academic Research, Doctor, Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Consejo Nacional de Investigaciones Científicas y Tecnológicas, y Universidad Nacional de Rosario, Suipacha 531, Rosario S2002 LRK, Argentina. mediavilla@ibr-conicet.gov.ar
Key Words	Bio-artificial liver; Ammonia detoxification; Device design; Ornithine Transcarbamylase; Rat liver microorgans; Carbamyl Phosphate Synthetase Ⅰ
Core Tip	This work describes the adaptation of a simplified bio-artificial liver (BAL) prototype to make it suitable to house rat liver microorgans (LMOs) as a biological component, and the evaluation of the performance in this new model. We demonstrate that the modification in the design of the artificial parts employed allows a good performance of LMOs, thus showing the importance of architecture and model configuration on the design of these devices. Besides its application as BAL, this mini bioreactor could serve as a suitable laboratory tool to evaluate the behavior and functionality of LMOs subjected to different incubation conditions due to its simple design and the utilization of standard materials.
Publish Date	2018-10-27 04:40
Citation	Pizarro MD, Mamprin ME, Daurelio LD, Rodriguez JV, Mediavilla MG. Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World J Hepatol 2018; 10(10): 719-730
URL	http://www.wjgnet.com/1948-5182/full/v10/i10/719.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i10.719

Full Article (PDF)	WJH-10-719.pdf
Full Article (Word)	WJH-10-719.doc
Manuscript File	39857-Review.docx
Answering Reviewers	39857-Answering reviewers.pdf
Audio Core Tip	39857-Audio core tip.mp3
Biostatistics Review Certificate	39857-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39857-Conflict-of-interest statement.pdf
Copyright License Agreement	39857-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39857-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	39857-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	39857-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	39857-Language certificate.pdf
Supplementary Material	39857-Supplementary material.pdf
Peer-review Report	39857-Peer-review(s).pdf
Scientific Misconduct Check	39857-Scientific misconduct check.pdf
Scientific Editor Work List	39857-Scientific editor work list.pdf