Publication Name	World Journal of Stem Cells
Manuscript ID	39955
Country	Spain

Received	2018-05-22 02:02
Peer-Review Started	2018-05-23 00:23
To Make the First Decision	2018-06-15 02:29
Return for Revision	2018-06-19 01:13
Revised	2018-06-26 00:56
Second Decision	2018-06-29 15:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-30 22:08
Articles in Press	2018-06-30 22:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-16 16:07
Typeset the Manuscript	2018-07-21 10:37
Publish the Manuscript Online	2018-07-26 11:35

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Stem cell therapy for faecal incontinence: Current state and future perspectives
Manuscript Source	Invited Manuscript
All Author List	Jacobo Trébol, Ana Carabias-Orgaz, Mariano García-Arranz and Damian García-Olmo
ORCID	Author(s) ORCID Number Jacobo Trébol http://orcid.org/0000-0002-6579-533X Ana Carabias-Orgaz http://orcid.org/000-0002-6579-533X Mariano García-Arranz http://orcid.org/0000-0002-6266-9055 Damian García-Olmo http://orcid.org/0000-0002-9369-2338
Funding Agency and Grant Number
Corresponding Author	Jacobo Trébol, MD, PhD, Surgeon, Surgical Oncologist, General and Digestive Tract Surgery Department, Salamanca University Healthcare Centre, Paseo de San Vicente, No. 58-182, Salamanca 37007, Spain. jtrebol@saludcastillayleon.es
Key Words	Faecal incontinence; Anal sphincter; Cell implantation; Tissue engineering; Cell therapy; Stem cells
Core Tip	Faecal incontinence is very frequent and is associated with severe consequences for patients. Available treatment outcomes are not optimal, particularly in the long-term. Stem cells, with or without bioengineering, could improve these results, as demonstrated in other clinical settings. We present a descriptive review of the published literature about faecal incontinence and stem cells, and discuss the existing limitations and concerns. Preclinical studies have confirmed the feasibility and safety of stem cells, and show some interesting results; the limited clinical experience confirms the safety and potential efficacy. However, further studies are needed to obtain clear conclusions.
Publish Date	2018-07-26 11:35
Citation	Trébol J, Carabias-Orgaz A, García-Arranz M, García-Olmo D. Stem cell therapy for faecal incontinence: Current state and future perspectives. World J Stem Cells 2018; 10(7): 82-105
URL	http://www.wjgnet.com/1948-0210/full/v10/i7/82.htm
DOI	http://dx.doi.org/10.4252/wjsc.v10.i7.82

Full Article (PDF)	WJSC-10-82.pdf
Full Article (Word)	WJSC-10-82.doc
Manuscript File	39955-Review.docx
Answering Reviewers	39955-Answering reviewers.pdf
Audio Core Tip	39955-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	39955-Conflict-of-interest statement.pdf
Copyright License Agreement	39955-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	39955-Language certificate.pdf
Peer-review Report	39955-Peer-review(s).pdf
Scientific Misconduct Check	39955-Scientific misconduct check.pdf
Scientific Editor Work List	39955-Scientific editor work list.pdf