Publication Name	World Journal of Gastroenterology
Manuscript ID	40099
Country	United States

Received	2018-06-01 01:12
Peer-Review Started	2018-06-01 02:55
To Make the First Decision	2018-07-04 01:18
Return for Revision	2018-07-06 03:01
Revised	2018-07-11 18:46
Second Decision	2018-07-20 06:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-07-21 17:52
Articles in Press	2018-07-21 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-16 06:56
Publish the Manuscript Online	2018-08-17 10:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Osteoporosis in primary biliary cholangitis
Manuscript Source	Invited Manuscript
All Author List	Christopher J Danford, Hirsh D Trivedi, Konstantinos Papamichail, Elliot B Tapper and Alan Bonder
ORCID	Author(s) ORCID Number Christopher J Danford http://orcid.org/0000-0003-0322-7705 Hirsh D Trivedi http://orcid.org/0000-0002-8328-9211 Konstantinos Papamichail http://orcid.org/0000-0003-1497-0254 Elliot B Tapper http://orcid.org/0000-0002-0839-1515 Alan Bonder http://orcid.org/0000-0001-6821-0416
Funding Agency and Grant Number
Corresponding Author	Alan Bonder, MD, Attending Doctor, Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, 110 Francis St. Suite 8E,, Boston, MA 02215, United States. abonder@bidmc.harvard.edu
Key Words	Biliary cirrhosis; Cholestatic liver disease; Osteopenia; Hepatic osteodystrophy; Bisphosphonates; Hormone replacement therapy
Core Tip	This article reviews the available literature on the pathophysiology and management of osteoporosis in primary biliary cholangitis (PBC). PBC-related osteoporosis is driven mainly by decreased bone formation as opposed to the increased bone resorption seen in postmenopausal osteoporosis. Despite this and a lack of evidence of efficacy, bisphosphonates remain the cornerstone of treatment. Future attention should be given to the use of anabolic bone agents in the treatment of PBC-related osteoporosis.
Publish Date	2018-08-17 10:48
Citation	Danford CJ, Trivedi HD, Papamichael K, Tapper EB, Bonder A. Osteoporosis in primary biliary cholangitis. World J Gastroenterol 2018; 24(31): 3513-3520
URL	http://www.wjgnet.com/1007-9327/full/v24/i31/3513.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i31.3513

Full Article (PDF)	WJG-24-3513.pdf
Full Article (Word)	WJG-24-3513.doc
Manuscript File	40099-Review.docx
Answering Reviewers	40099-Answering reviewers.pdf
Audio Core Tip	40099-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40099-Conflict-of-interest statement.pdf
Copyright License Agreement	40099-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40099-Grant application form(s).pdf
Peer-review Report	40099-Peer-review(s).pdf
Scientific Misconduct Check	40099-Scientific misconduct check.pdf
Scientific Editor Work List	40099-Scientific editor work list.pdf