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Articles Published Processes
9/25/2018 3:44:36 AM | Browse: 1278 | Download: 2906
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Received |
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2018-06-05 08:47 |
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Peer-Review Started |
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2018-06-05 09:21 |
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First Decision by Editorial Office Director |
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2018-06-20 22:57 |
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Return for Revision |
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2018-06-25 02:30 |
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Revised |
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2018-07-30 01:29 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-07-31 12:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-08-01 04:28 |
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Articles in Press |
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2018-08-01 04:28 |
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Edit the Manuscript by Language Editor |
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2018-08-10 19:05 |
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Typeset the Manuscript |
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2018-09-20 07:59 |
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Publish the Manuscript Online |
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2018-09-25 03:44 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-Catenin signalling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gan-Rong Huang, Si-Jun Wei, Yan-Qiang Huang, Wei Xing, Lu-Yao Wang and Lin-Ling Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi key disciplines (Pathogen Biology) |
[2013] 16 |
| key laboratory cultivation base of universities in Guangxi |
Guangxi Education Research [2014] 6 |
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| Corresponding Author |
Wei Xing, MD, Academic Research, Chief Doctor, Pharmacist, Professor, Teacher, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, 98 Urban-Rural Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. 116895009@qq.com |
| Key Words |
Carbon tetrachloride; Hepatic fibrosis; Vitamin D; Puerarin; Wnt/β-Catenin |
| Core Tip |
The proliferation of hepatic stellate cells (HSCs) is associated with hepatic fibrosis. The activated HSCs, as well as Wnt1 and β-Catenin, have become important targets in anti-hepatic fibrosis therapy. This research investigated the protective effect of the combined use of vitamin D and puerarin against CCl4-induced hepatic fibrosis in rats. The protective effect of the combined use of vitamin D and puerarin in the progression of hepatic fibrosis is closely associated with the function of silencing the Wnt1/β-Catenin pathway, suppressing the activation of HSCs, and decreasing the secretion of collagen fibers, which provided a useful reference for those in clinical practice. |
| Publish Date |
2018-09-25 03:44 |
| Citation |
Huang GR, Wei SJ, Huang YQ, Xing W, Wang LY, Liang LL. Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-Catenin signalling pathway. World J Gastroenterol 2018; 24(36): 4178-4185 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i36/4178.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i36.4178 |
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