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9/25/2018 3:44:36 AM | Browse: 832 | Download: 1486
Publication Name World Journal of Gastroenterology
Manuscript ID 40167
Country/Territory China
Received
2018-06-05 08:47
Peer-Review Started
2018-06-05 09:21
To Make the First Decision
2018-06-21 01:05
Return for Revision
2018-06-25 02:30
Revised
2018-07-30 01:29
Second Decision
2018-07-31 12:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-01 04:28
Articles in Press
2018-08-01 04:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-08-10 19:05
Typeset the Manuscript
2018-09-20 07:59
Publish the Manuscript Online
2018-09-25 03:44
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-Catenin signalling pathway
Manuscript Source Unsolicited Manuscript
All Author List Gan-Rong Huang, Si-Jun Wei, Yan-Qiang Huang, Wei Xing, Lu-Yao Wang and Lin-Ling Liang
ORCID
Author(s) ORCID Number
Gan-Rong Huang http://orcid.org/0000-0001-5580-8689
Si-Jun Wei http://orcid.org/0000-0001-6948-2747
Yan-Qiang Huang http://orcid.org/0000-0002-2121-8258
Wei Xing http://orcid.org/0000-0001-5640-1151
Lu-Yao Wang http://orcid.org/0000-0001-5545-0170
Lin-Ling Liang http://orcid.org/0000-0002-1498-2370
Funding Agency and Grant Number
Funding Agency Grant Number
Guangxi key disciplines (Pathogen Biology) [2013] 16
key laboratory cultivation base of universities in Guangxi Guangxi Education Research [2014] 6
Corresponding Author Wei Xing, MD, Academic Research, Chief Doctor, Pharmacist, Professor, Teacher, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, 98 Urban-Rural Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. 116895009@qq.com
Key Words Carbon tetrachloride; Hepatic fibrosis; Vitamin D; Puerarin; Wnt/β-Catenin
Core Tip The proliferation of hepatic stellate cells (HSCs) is associated with hepatic fibrosis. The activated HSCs, as well as Wnt1 and β-Catenin, have become important targets in anti-hepatic fibrosis therapy. This research investigated the protective effect of the combined use of vitamin D and puerarin against CCl4-induced hepatic fibrosis in rats. The protective effect of the combined use of vitamin D and puerarin in the progression of hepatic fibrosis is closely associated with the function of silencing the Wnt1/β-Catenin pathway, suppressing the activation of HSCs, and decreasing the secretion of collagen fibers, which provided a useful reference for those in clinical practice.
Publish Date 2018-09-25 03:44
Citation Huang GR, Wei SJ, Huang YQ, Xing W, Wang LY, Liang LL. Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-Catenin signalling pathway. World J Gastroenterol 2018; 24(36): 4178-4185
URL http://www.wjgnet.com/1007-9327/full/v24/i36/4178.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i36.4178
Full Article (PDF) WJG-24-4178.pdf
Full Article (Word) WJG-24-4178.doc
Manuscript File 40167-Review.docx
Answering Reviewers 40167-Answering reviewers.pdf
Audio Core Tip 40167-Audio core tip.m4a
Biostatistics Review Certificate 40167-Biostatistics-Review-Certificate-revision.jpg
Conflict-of-Interest Disclosure Form 40167-Conflict-of-interest statement.pdf
Copyright License Agreement 40167-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40167-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 40167-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 40167-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 40167-Language certificate.pdf
Peer-review Report 40167-Peer-review(s).pdf
Scientific Misconduct Check 40167-Scientific misconduct check.pdf
Scientific Editor Work List 40167-Scientific editor work list.pdf