Publication Name	World Journal of Gastroenterology
Manuscript ID	4020
Country	Denmark

Received	2013-06-08 15:26
Peer-Review Started	2013-06-08 18:20
To Make the First Decision	2013-07-05 18:29
Return for Revision	2013-07-18 16:29
Revised	2013-08-05 17:51
Second Decision	2013-08-20 12:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 13:31
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-28 14:04
Publish the Manuscript Online	2013-11-18 10:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pharmacological pain management in chronic pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Søren S Olesen, Jacob Juel, Carina Graversen, Yuri Kolesnikov, Oliver HG Wilder-Smith and Asbjørn M Drewes
Funding Agency and Grant Number	Funding Agency Grant Number Karen Elise Jensen`s Foundation Danish Council for Strategic research Danish Agency for Science, Technology and Innovation
Corresponding Author	Søren S Olesen, MD, PhD, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark. sso@mech-sense.com
Key Words	Chronic pancreatitis; Pain; Treatment; Pharmacology; Analgesics; Adjuvant analgesics
Core Tip	Pharmacological pain management in chronic pancreatitis is complicated and requires a multidisciplinary approach. Identification of risk factors associated with disease progression and evaluation of extra pancreatic causes of pain and complications is essential in all patients. Analgesics are typically titrated according to the World Health Organization ladder principle, but in some situations a top-down approach may be useful to control pain and avoid sensitization of central pain pathways. Adjuvant analgesics and combinations of drugs should be considered at an early stage. Non-encapsulated enzyme therapy, somastotatin-analogues and antioxidants can be considered as supplements to conventional analgesics in special situations.
Publish Date	2013-11-18 10:59
Citation	Olesen SS, Juel J, Graversen C, Kolesnikov Y, Wilder-Smith OHG, Drewes AM. Pharmacological pain management in chronic pancreatitis. World J Gastroenterol 2013; 19(42): 7292-7301
URL	http://www.wjgnet.com/1007-9327/full/v19/i42/7292.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i42.7292

Full Article (PDF)	WJG-19-7292.pdf
Manuscript File	4020-Review.docx
Answering Reviewers	4020-Answering reviewers.pdf
Copyright License Agreement	4020-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4020-Language certificate.pdf
Peer-review Report	4020-Peer reviewer(s).pdf
Scientific Editor Work List	4020-Scientific editor work list.doc