| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Optimal immunosuppressor induces stable gut microbiota after liver transplantation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian-Wen Jiang, Zhi-Gang Ren, Hai-Feng Lu, Hua Zhang, Ang Li, Guang-Ying Cui, Jun-Jun Jia, Xin-Hua Chen, Hai-Yang Xie, Yong He, Li Jiang and Lan-Juan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
(81672422, 81600506, and 81702757) |
| Open Project in State Key Laboratory for Diagnosis and Treatment of Infectious Disease |
2015KF03 |
| National S&T Major Project of China |
2018ZX10301201 |
| Natural Science Foundation of Zhejiang Province |
LY15H160033 |
| Zhejiang Province Health Department Program |
(2014KYB081, 2017KY322) |
| China Postdoctoral Science Foundation |
2017464 |
|
| Corresponding Author |
Lan-Juan Li, MD, PhD, Academic Research, Doctor, Doctor, Professor, Senior Researcher, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn |
| Key Words |
Liver transplantation; Graft function; Gut microbiota; Immunosuppressor; Tacrolimus; Rejection; Denaturing gradient gel electrophoresis |
| Core Tip |
This is the first study to illustrate the effects of different dosages of Tacrolimus (FK506) on gut microbiota following liver transplantation (LT) and indicates that an optimal dosage of FK506 induces effective immunosupression, good graft function and stable gut microbiota after LT in rats. Based on the relationship between gut microbiota and the immunosuppressive dosage in this study, we can not only illustrate precise changes of gut microbiota given by different dosages of FK-506 following LT, but we also provide a novel monitoring strategy based on changes in gut microbiota for immunosuppressive dosage assessment in patients following LT. |
| Publish Date |
2018-09-14 05:53 |
| Citation |
Jiang JW, Ren ZG, Lu HF, Zhang H, Li A, Cui GY, Jia JJ, Xie HY, Chen XH, He Y, Jiang L, Li LJ. optimal immunosuppressor induces stable gut microbiota after liver transplantation. World J Gastroenterol 2018; 24(34): 3871-3883 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i34/3871.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i34.3871 |
