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9/14/2018 5:53:04 AM | Browse: 847 | Download: 1608
Publication Name World Journal of Gastroenterology
Manuscript ID 40321
Country/Territory China
Received
2018-06-21 03:33
Peer-Review Started
2018-06-21 07:47
To Make the First Decision
2018-07-18 01:04
Return for Revision
2018-07-18 04:13
Revised
2018-07-24 16:01
Second Decision
2018-07-31 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-01 04:19
Articles in Press
2018-08-01 04:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-08-13 22:53
Typeset the Manuscript
2018-09-05 07:23
Publish the Manuscript Online
2018-09-14 05:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Basic Study
Article Title Optimal immunosuppressor induces stable gut microbiota after liver transplantation
Manuscript Source Unsolicited Manuscript
All Author List Jian-Wen Jiang, Zhi-Gang Ren, Hai-Feng Lu, Hua Zhang, Ang Li, Guang-Ying Cui, Jun-Jun Jia, Xin-Hua Chen, Hai-Yang Xie, Yong He, Li Jiang and Lan-Juan Li
ORCID
Author(s) ORCID Number
Jian-Wen Jiang http://orcid.org/0000-0003-3745-1254
Zhi-Gang Ren http://orcid.org/0000-0002-0913-0130
Hai-Feng Lu http://orcid.org/0000-0003-2886-5615
Hua Zhang http://orcid.org/0000-0001-7333-9548
Ang Li http://orcid.org/0000-0003-4685-4752
Guang-Ying Cui http://orcid.org/0000-0003-3656-8100
Jun-Jun Jia http://orcid.org/0000-0002-1495-2390
Xin-Hua Chen http://orcid.org/0000-0002-4573-9111
Hai-Yang Xie http://orcid.org/0000-0002-6913-9284
Yong He http://orcid.org/0000-0003-4814-7880
Li Jiang http://orcid.org/0000-0002-6461-3354
Lan-Juan Li http://orcid.org/0000-0001-6945-0593
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (81672422, 81600506, and 81702757)
Open Project in State Key Laboratory for Diagnosis and Treatment of Infectious Disease 2015KF03
National S&T Major Project of China 2018ZX10301201
Natural Science Foundation of Zhejiang Province LY15H160033
Zhejiang Province Health Department Program (2014KYB081, 2017KY322)
China Postdoctoral Science Foundation 2017464
Corresponding Author Lan-Juan Li, MD, PhD, Academic Research, Doctor, Professor, Senior Researcher, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn
Key Words Liver transplantation; Graft function; Gut microbiota; Immunosuppressor; Tacrolimus; Rejection; Denaturing gradient gel electrophoresis
Core Tip This is the first study to illustrate the effects of different dosages of Tacrolimus (FK506) on gut microbiota following liver transplantation (LT) and indicates that an optimal dosage of FK506 induces effective immunosupression, good graft function and stable gut microbiota after LT in rats. Based on the relationship between gut microbiota and the immunosuppressive dosage in this study, we can not only illustrate precise changes of gut microbiota given by different dosages of FK-506 following LT, but we also provide a novel monitoring strategy based on changes in gut microbiota for immunosuppressive dosage assessment in patients following LT.
Publish Date 2018-09-14 05:53
Citation Jiang JW, Ren ZG, Lu HF, Zhang H, Li A, Cui GY, Jia JJ, Xie HY, Chen XH, He Y, Jiang L, Li LJ. optimal immunosuppressor induces stable gut microbiota after liver transplantation. World J Gastroenterol 2018; 24(34): 3871-3883
URL http://www.wjgnet.com/1007-9327/full/v24/i34/3871.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i34.3871
Full Article (PDF) WJG-24-3871.pdf
Full Article (Word) WJG-24-3871.doc
The ARRIVE Guidelines 40321-The ARRIVE guidelines.pdf
Manuscript File 40321-Review.docx
Answering Reviewers 40321-Answering reviewers.pdf
Audio Core Tip 40321-Audio core tip.mp3
Biostatistics Review Certificate 40321-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40321-Conflict-of-interest statement.pdf
Copyright License Agreement 40321-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40321-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 40321-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 40321-Institutional-Review-Board-Approval-Form-or-Document-revision.pdf
Non-Native Speakers of English Editing Certificate 40321-Language certificate.pdf
Supplementary Material 40321-Supplementary material.pdf
Peer-review Report 40321-Peer-review(s).pdf
Scientific Misconduct Check 40321-Scientific misconduct check.pdf
Scientific Editor Work List 40321-Scientific editor work list.pdf