Publication Name	World Journal of Hepatology
Manuscript ID	4044
Country	Egypt

Received	2013-06-11 09:35
Peer-Review Started	2013-06-13 09:32
To Make the First Decision	2013-06-24 10:22
Return for Revision	2013-07-04 15:33
Revised	2013-07-29 17:10
Second Decision	2013-08-06 11:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-06 12:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-08-27 08:27
Publish the Manuscript Online	2013-09-20 12:54

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Autobiography
Article Title	Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C
Manuscript Source	Invited Manuscript
All Author List	Behairy E Behairy, Ghada M El-Mashad, Ragab S Abd-Elghany, Enas M Ghoneim and Mostafa M Sira
Funding Agency and Grant Number	Funding Agency Grant Number National Liver Institute, Menofiya University, Egypt
Corresponding Author	Dr. Mostafa M Sira, Department of Pediatric Hepatology, National Liver Institute, Menofiya University, POBox 32511, Gamal Abdel Nasser St., 32511 Shebin El-koom, Menofiya, Egypt. msira@liver-eg.org
Key Words	Children; Hepatitis C virus; Complement C4a; Liver biopsy; Liver fibrosis
Core Tip	Non-invasive prediction of liver fibrosis is a challenging issue especially in pediatric population. Complement C4a was found, by proteomic analysis, to be associated with liver fibrosis and therefore proposed as a candidate for fibrosis prediction. In adults, serum C4 was found to decrease in hepatitis C virus (HCV) patients with moderate fibrosis and cirrhosis compared to healthy controls. In addition, in advanced HCV-induced liver fibrosis, the net production of C4a was found to be down-regulated. Furthermore, it was found to correlate negatively with alanine transaminase and the histological activity index of the Knodell scoring system. The issue has never been investigated in children before.
Publish Date	2013-09-20 12:54
Citation	Behairy BE, El-Mashad GM, Abd-Elghany RS, Ghoneim EM, Sira MM. Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C. World J Hepatol 2013; 5(8): 445-451
URL	http://www.wjgnet.com/1948-5182/full/v5/i8/445.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i8.445

Full Article (PDF)	WJH-5-445.pdf
Manuscript File	4044-Review.docx
Answering Reviewers	4044-Answering reviewers.pdf
Copyright License Agreement	4044-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	4044-Language certificate.pdf
Peer-review Report	4044-Peer reviews.pdf
Scientific Editor Work List	4044-Scientific editor work list.doc