Publication Name	World Journal of Gastroenterology
Manuscript ID	40462
Country	China

Received	2018-07-01 13:16
Peer-Review Started	2018-07-02 11:37
First Decision by Editorial Office Director	2018-07-24 17:03
Return for Revision	2018-07-25 03:26
Revised	2018-08-16 13:51
Publication Fee Transferred
Second Decision by Editor	2018-09-04 08:06
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-10-05 23:25
Articles in Press	2018-10-05 23:25
Edit the Manuscript by Language Editor	2018-10-15 00:59
Typeset the Manuscript	2018-10-22 07:28
Publish the Manuscript Online	2018-10-26 11:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Outcomes of furazolidone- and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Wen Zhang, Wei-Ling Hu, Yuan Cai, Wen-Fang Zheng, Qin Du, John J Kim, John Y Kao, Ning Dai and Jian-Min Si
ORCID	Author(s) ORCID Number Ya-Wen Zhang http://orcid.org/0000-0002-6867-0399 Wei-Ling Hu http://orcid.org/0000-0002-9145-7027 Yuan Cai http://orcid.org/0000-0003-2356-1399 Wen-Fang Zheng http://orcid.org/0000-0002-4646-0518 Qin Du http://orcid.org/0000-0002-6840-8358 John J Kim http://orcid.org/0000-0003-4341-8661 John Y Kao http://orcid.org/0000-0001-5338-4587 Ning Dai http://orcid.org/0000-0003-0749-9230 Jian-Min Si http://orcid.org/0000-0002-1254-7949
Funding Agency and Grant Number	Funding Agency Grant Number the Zhejiang Science and Technology Project LGF18H160012
Corresponding Author	Wei-Ling Hu, MD, PhD, Doctor, Doctor, Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Institute of Gastroenterology, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. huweiling@zju.edu.cn
Key Words	Helicobacter pylori; Furazolidone; Quadruple regimen; Side effects; Eradication
Core Tip	This study examined the outcomes of fura­zolidone- and amoxicillin-based quadruple therapy as both primary and rescue therapies for Helicobacter pylori (H. pylori) infection in nearly a thousand patients. Detailed data on adverse events and factors associ­ated with failed H. pylori eradication were evaluated. Furazolidone- and amoxicillin-based quadruple the­rapy demonstrated a high H. pylori eradication rate exceeding 90% with a favorable safety profile in a real-world setting. Abstinence from alcohol during therapy and strict medication adherence may further optimize eradication. The results validate updated guidelines recommending furazolidone-based quadruple therapy as a first-line treatment for H. pylori infection in areas with a high prevalence of clarithromycin resistance.
Publish Date	2018-10-26 11:38
Citation	Zhang YW, Hu WL, Cai Y, Zheng WF, Du Q, Kim JJ, Kao YJ, Dai N, Si JM. Outcomes of furazolidone- and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication. World J Gastroenterol 2018; 24(40): 4596-4605
URL	http://www.wjgnet.com/1007-9327/full/v24/i40/4596.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i40.4596

Full Article (PDF)	WJG-24-4596.pdf
Full Article (Word)	WJG-24-4596.doc
Manuscript File	40462-Review.docx
Answering Reviewers	40462-Answering reviewers.pdf
Audio Core Tip	40462-Audio core tip.mp3
Biostatistics Review Certificate	40462-Biostatistics Review Certificate.pdf
Conflict-of-Interest Disclosure Form	40462-Conflict-of-interest statement.pdf
Copyright License Agreement	40462-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	40462-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	40462-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	40462-Language certificate.pdf
Supplementary Material	40462-Supplementary material.pdf
Peer-review Report	40462-Peer-review(s).pdf
Scientific Misconduct Check	40462-Scientific misconduct check.pdf
Scientific Editor Work List	40462-Scientific editor work list.pdf