Publication Name	World Journal of Gastroenterology
Manuscript ID	4053
Country	Brazil

Received	2013-06-11 22:03
Peer-Review Started	2013-06-12 19:04
To Make the First Decision	2013-07-05 18:38
Return for Revision	2013-07-18 11:30
Revised	2013-08-03 09:20
Second Decision	2013-08-19 12:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 00:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-14 18:20
Publish the Manuscript Online	2013-11-08 14:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil
Manuscript Source	Invited Manuscript
All Author List	Luís Carlos Moreira Antunes, João Carlos Prolla, Antonio de Barros Lopes, Marta Pires da Rocha and Renato Borges Fagundes
Funding Agency and Grant Number
Corresponding Author	Renato Borges Fagundes, MD, PhD, Professor of Medicine, Programa de Pós-Graduação: Ciências em Gastroenterologia e Hepatologia - Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2400 - 2° andar, Bairro Santana, Porto Alegre 90035-003, Rio Grande do Sul, Brasil. fagundesrb@gmail.com
Key Words	Esophageal cancer; Esophageal squamous cell carcinoma; Human papillomavirus; Head and neck cancer; Polymerase chain reactions; Nested-polymerase chain reaction
Core Tip	This paper gives additional evidence related to the controversy on the potential role of human papillomavirus (HPV) in the pathogenesis of esophageal squamous cell carcinoma (ESCC). Taking great care to avoid contamination by environmental HPV and using a very sensitive HPV DNA detection technique, we found no evidence of HPV neither in ESCC tumor tissue, nor in esophageal non-tumoral tissue from ESCC patients, or from head and neck squamous cell carcinoma patients or from dyspeptic controls without cancer. These data convincingly argue that when environmental contamination is carefully controlled, there is no evidence that HPV is involved in ESCC carcinogenesis in southern Brazil.
Publish Date	2013-11-08 14:06
Citation	Antunes LCM, Prolla JC, de Barros Lopes A, da Rocha MP, Fagundes RB. No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil. World J Gastroenterol 2013; 19(39): 6598-6603
URL	http://www.wjgnet.com/1007-9327/full/v19/i39/6598.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i39.6598

Full Article (PDF)	WJG-19-6598.pdf
Manuscript File	4053-Review.docx
Answering Reviewers	4053-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician Review Report.pdf
Copyright License Agreement	4053-Copyright assignment.doc
Institutional Review Board Approval Form or Document	Scientific Committee and Research Ethical Comission.pdf
Non-Native Speakers of English Editing Certificate	4053-Language certificate.pdf
Peer-review Report	4053-Peer reviewer(s).pdf
Scientific Editor Work List	4053-Scientific editor work list.doc