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Articles Published Processes
10/27/2018 4:40:10 AM | Browse: 914 | Download: 1629
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Received |
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2018-07-03 01:07 |
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Peer-Review Started |
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2018-07-03 06:20 |
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To Make the First Decision |
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2018-07-24 23:47 |
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Return for Revision |
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2018-07-25 03:05 |
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Revised |
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2018-07-27 08:59 |
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Second Decision |
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2018-08-10 07:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-08-13 02:35 |
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Articles in Press |
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2018-08-13 02:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-08-22 17:59 |
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Typeset the Manuscript |
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2018-10-12 11:58 |
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Publish the Manuscript Online |
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2018-10-27 04:40 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Spleen stiffness mirrors changes in portal hypertension after successful interferon-free therapy in chronic-hepatitis C virus patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Federico Ravaioli, Antonio Colecchia, Elton Dajti, Giovanni Marasco, Luigina Vanessa Alemanni, Mariarosa Tamè, Francesco Azzaroli, Stefano Brillanti, Giuseppe Mazzella and Davide Festi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Antonio Colecchia, MD, Unit of Gastroenterology, Borgo Trento University Hospital, Verona 37100, Italy. antonio.colecchia@aovr.veneto.it |
| Key Words |
Clinically significant portal hypertension; Spleen stiffness measurement; Advanced chronic liver disease; Direct-acting antivirals; Portal hypertension; Hepatitis C; Non-invasive test |
| Core Tip |
Liver stiffness measurement (LSM) and spleen stiffness measurement (SSM) are widely validated surrogates of portal hypertension (PH) and its complications. Their role in the assessment of therapy response, such as treatment with direct-acting antivirals (DAAs) of hepatitis C virus patients, is still under investigation. We demonstrated in a large cohort that not only LSM, but also SSM, is reduced six months after successful DAA therapy. As opposed to LSM, SSM directly reflects PH and is less influenced by the immediate reduction of liver necro-inflammation. We believe that SSM could represent a helpful tool for the clinician in the follow-up of these patients. |
| Publish Date |
2018-10-27 04:40 |
| Citation |
Ravaioli F, Colecchia A, Dajti E, Marasco G, Alemanni LV, Tamè M, Azzaroli F, Brillanti S, Mazzella G, Festi D. Spleen stiffness mirrors changes in portal hypertension after successful interferon-free therapy in chronic-hepatitis C virus patients. World J Hepatol 2018; 10(10): 731-742 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i10/731.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i10.731 |
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