Publication Name	World Journal of Neurology
Manuscript ID	4079
Country	United States

Received	2013-06-13 10:00
Peer-Review Started	2013-06-13 11:29
To Make the First Decision	2013-07-05 18:24
Return for Revision	2013-07-15 11:29
Revised	2013-07-27 07:41
Second Decision	2013-08-20 10:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 12:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-23 17:10
Publish the Manuscript Online	2013-09-26 18:43

ISSN	2218-6212 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Editorial
Article Title	Common genetic mechanism underlying susceptibility to posttraumatic stress disorder
Manuscript Source	Invited Manuscript
All Author List	Zhen He, Li Cui, Bei He, Sherry A Ferguson and Merle G Paule
Funding Agency and Grant Number	Funding Agency Grant Number Mayo Foundation, Mayo Clinic Jacksonville, Florida National Center for Toxicological Research/FDA P00710 (to He Z) UAMS Hornick Award (to Cui L)
Corresponding Author	Zhen He, MD, PhD, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, United States. zhen.he@fda.hhs.gov
Key Words	Amygdalar damage; Anxiety behavior; Microarrays; Microdissection; Microtubule-associated protein tau; Post-traumatic stress disorder; RNA quality
Core Tip	We propose that susceptibility to post-traumatic stress disorder (PTSD) may be determined, in part, by aberrant microtubule-associated protein tau expression in neurons of critical brain structures. We review several lines of evidence to support this novel hypothesis. In addition, we review types of PTSD, namely non-classical PTSD, induced by various medical conditions and address this issue of why non-classical PTSD can be reliably elicited. To verify our hypothesis, we propose to use animal models of PTSD combined with laser-assisted/capture microdissection and microarray analysis to examine gene expression changes in selected cellular elements in response to the occurrence of PTSD.
Publish Date	2013-09-26 18:43
Citation	He Z, Cui L, He B, Ferguson SA, Paule MG. A common genetic mechanism underlying susceptibility to posttraumatic stress disorder. World J Neurol 2013; 3(3): 14-24
URL	http://www.wjgnet.com/2218-6212/full/v3/i3/14.htm
DOI	http://dx.doi.org/10.5316/wjn.v3.i3.14

Full Article (PDF)	WJN-3-14.pdf
Manuscript File	4079-Review.docx
Answering Reviewers	4079-Answering reviewers.pdf
Copyright License Agreement	4079-Copyright assignment.pdf
Peer-review Report	4079-Peer reviews.pdf
Scientific Editor Work List	4079-Scientific editor work list.doc