Publication Name	World Journal of Gastroenterology
Manuscript ID	40874
Country	Poland

Received	2018-07-16 05:03
Peer-Review Started	2018-07-16 05:54
To Make the First Decision	2018-07-25 01:17
Return for Revision	2018-07-25 04:01
Revised	2018-08-15 03:39
Second Decision	2018-08-20 08:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-24 09:11
Articles in Press	2018-08-24 09:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-20 08:23
Publish the Manuscript Online	2018-09-25 03:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Differential expression of mucin 1 and mucin 2 in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Aldona Kasprzak, Elzbieta Siodla, Malgorzata Andrzejewska, Jacek Szmeja, Agnieszka Seraszek-Jaros, Szczepan Cofta and Witold Szaflarski
ORCID	Author(s) ORCID Number Aldona Kasprzak http://orcid.org/0000-0002-1773-3038 Elzbieta Siodla http://orcid.org/0000-0003-2614-219X Malgorzata Andrzejewska http://orcid.org/0000-0003-4980-1725 Jacek Szmeja http://orcid.org/0000-0003-0289-3511 Agnieszka Seraszek-Jaros http://orcid.org/0000-0003-4787-1033 Szczepan Cofta http://orcid.org/0000-0002-8849-5487 Witold Szaflarski http://orcid.org/0000-0001-5059-268X
Funding Agency and Grant Number	Funding Agency Grant Number National Science Center in Poland 2015/17/B/NZ7/03043
Corresponding Author	Aldona Kasprzak, MD, PhD, Professor, Department of Histology and Embryology, Poznan University of Medical Sciences, Święcickiego 6, Poznan 60-781, Poland. akasprza@ump.edu.pl
Key Words	Mucins; Real-time quantitative polymerase chain reaction; Colorectal cancer; Immunohistochemistry; HSV filter program
Core Tip	Colorectal cancers (CRC) represent the second most widely manifested malignant tumor worldwide in women and third in men. The evident expression of two mucins [mucin 1 (MUC1) and mucin 2 (MUC2)] occurs in a normal and cancerous large intestine. Using RT-qPCR analysis and immunohistochemistry we confirmed higher expression of the MUC1 mRNA, lower MUC2 protein, and higher MUC1/MUC2 expression ratio in CRC samples as compared to the control. MUC2 protein ex­pression correlates with increased cellular proliferation. A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 may be a useful factor of poor prognosis in CRC patients.
Publish Date	2018-09-25 03:44
Citation	Kasprzak A, Siodła E, Andrzejewska M, Szmeja J, Seraszek-Jaros A, Cofta S, Szaflarski W. Differential expression of mucin 1 and mucin 2 in colorectal cancer. World J Gastroenterol 2018; 24(36): 4164-4177
URL	http://www.wjgnet.com/1007-9327/full/v24/i36/4164.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i36.4164

Full Article (PDF)	WJG-24-4164.pdf
Full Article (Word)	WJG-24-4164.doc
Manuscript File	40874-Review.docx
Answering Reviewers	40874-Answering reviewers.pdf
Audio Core Tip	40874-Audio core tip.mp3
Biostatistics Review Certificate	40874-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	40874-Conflict-of-interest statement.pdf
Copyright License Agreement	40874-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40874-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	40874-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	40874-Language certificate.pdf
Peer-review Report	40874-Peer-review(s).pdf
Scientific Misconduct Check	40874-Scientific misconduct check.pdf
Scientific Editor Work List	40874-Scientific editor work list.pdf