Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	40925
Country	Japan

Received	2018-07-20 01:51
Peer-Review Started	2018-07-20 06:49
To Make the First Decision	2018-09-03 01:40
Return for Revision	2018-09-03 09:18
Revised	2018-09-06 03:58
Second Decision	2018-10-17 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-10-17 23:44
Articles in Press	2018-10-17 23:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-09 07:28
Publish the Manuscript Online	2018-11-15 13:34

ISSN	1948-5204 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Prospective Study
Article Title	Raman spectroscopy for the diagnosis of unlabeled and unstained histopathological tissue specimens
Manuscript Source	Invited Manuscript
All Author List	Haruo Ikeda, Hiroaki Ito, Muneaki Hikita, Noriko Yamaguchi, Naoyuki Uragami, Noboru Yokoyama, Yuko Hirota, Miki Kushima, Yoichi Ajioka and Haruhiro Inoue
ORCID	Author(s) ORCID Number Haruo Ikeda http://orcid.org/https://orcid.org/0000-0002-1690-8422 Hiroaki Ito http://orcid.org/https://orcid.org/0000-0002-0761-0632 Muneaki Hikita http://orcid.org/https://orcid.org/0000-0002-7495-3344 Noriko Yamaguchi http://orcid.org/https://orcid.org/0000-0003-2368-8250 Naoyuki Uragami http://orcid.org/https://orcid.org/0000-0003-2974-8250 Noboru Yokoyama http://orcid.org/https://orcid.org/0000-0003-1882-0018 Yuko Hirota http://orcid.org/https://orcid.org/0000-0001-8898-5315 Miki Kushima http://orcid.org/https://orcid.org/0000-0002-1642-0478 Yoichi Ajioka http://orcid.org/https://orcid.org/0000-0002-7532-5454 Haruhiro Inoue http://orcid.org/https://orcid.org/0000-0002-0551-7274
Funding Agency and Grant Number	Funding Agency Grant Number The Japan Society for the Promotion of Science (JSPS) JP26460688 and JP17K09022
Corresponding Author	Hiroaki Ito, MD, PhD, Associate Professor, Department of Surgery, Digestive Disease Center, Showa University Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo 1358577, Japan. h.ito@med.showa-u.ac.jp
Key Words	Label-free analysis; Raman spectroscopy; Histopathological examination; Gastric cancer
Core Tip	We investigated the possibility of diagnosing gastric cancer from an unstained pathological tissue using Raman spectroscopy, and the findings were compared to those obtained with conventional histopathology. We analyzed unstained gastric pathological specimens by Raman spectroscopy. The Raman scattering spectrum intensity ratios of 782 cm-1/620 cm-1, 782 cm-1/756 cm-1, 782 cm-1/1250 cm-1, and 782 ​​cm-1/1263 cm-1 in the gastric adenocarcinoma tissue were significantly higher than those in the normal stomach tissue. The results of this preliminary experiment suggest the feasibility of our spectroscopic method as a diagnostic tool for gastric cancer using unstained pathological specimens.
Publish Date	2018-11-15 13:34
Citation	Ikeda H, Ito H, Hikita M, Yamaguchi N, Uragami U, Yokoyama N, Hirota Y, Kushima M, Ajioka Y, Inoue H. Raman spectroscopy for the diagnosis of unlabeled and unstained histopathological tissue specimens. World J Gastrointest Oncol 2018; 10(11): 439-448
URL	http://www.wjgnet.com/1948-5204/full/v10/i11/439.htm
DOI	http://dx.doi.org/10.4251/wjgo.v10.i11.439

Full Article (PDF)	WJGO-10-439.pdf
Full Article (Word)	WJGO-10-439.doc
CONSORT 2010 Statement	40925-CONSORT 2010 statement.pdf
Manuscript File	40925-Review.docx
Answering Reviewers	40925-Answering reviewers.pdf
Audio Core Tip	40925-Audio core tip.mp3
Biostatistics Review Certificate	40925-Biostatistics statement.pdf
Clinical Trial Registration Statement	40925-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	40925-Conflict-of-interest statement.pdf
Copyright License Agreement	40925-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40925-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	40925-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	40925-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	40925-Language certificate.pdf
Peer-review Report	40925-Peer-review(s).pdf
Scientific Misconduct Check	40925-Scientific misconduct check.pdf
Scientific Editor Work List	40925-Scientific editor work list.pdf