| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Genetic associations of inflammatory bowel disease in a South Asian population
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Madunil Anuk Niriella, Isurujith Kongala Liyanage, Senerath Kuleesha Kodisinghe, Arjuna Priyadarsin De Silva, Nimna Rajapakshe, Sunali D Nanayakkara, Dunya Luke, Thilakshi Silva, Metthananda Nawarathne, Ranjith K Peiris, Udaya P Kalubovila, Sujeewa R Kumarasena, Vajira Harshadeva Weerabaddana Dissanayake, Rohan W Jayasekara and Hithanadura Janaka de Silva |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Council, Sri Lanka |
NRC 13-108 |
|
| Corresponding Author |
Madunil Anuk Niriella, Department of Clinical Medicine, Faculty of Medicine, University of Kelaniya, Ragama GQ 10110, Sri Lanka. maduniln@yahoo.co.uk |
| Key Words |
Inflammatory bowel disease; Genetics of inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; LAMB1 gene mutation; IL-12B gene mutation |
| Core Tip |
This is a case-control study looking at the prevalence of genetic mutations, ones that are commonly associated with inflammatory bowel disease (IBD) among Caucasians, in a South Asian population from Sri Lanka. Most allelic variants studied were not seen in this population, confirming the heterogeneity of the genetic composition of IBD between South Asians and Caucasian patients. We found positive associations between rs886774 (LAMB1-gene) and ulcerative colitis, which was also associated with a milder disease and increased remission rate. Patients with upper gastrointestinal involvement of Crohn’s disease were more likely to have the mutation rs10045431 (IL 12B gene). |
| Publish Date |
2018-12-06 13:35 |
| Citation |
Niriella MA, Liyanage IK, Kodisinghe SK, De Silva AP, Rajapakshe N, Nanayakkara SD, Luke D, Silva T, Nawarathne M, Peiris RK, Kalubovila UP, Kumarasena SR, Dissanayake VH, Jayasekara RW, de Silva HJ. Genetic associations of inflammatory bowel disease in a South Asian population. World J Clin Cases 2018; 6(15): 908-915 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i15/908.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i15.908 |
