Publication Name	World Journal of Gastroenterology
Manuscript ID	40991
Country	Canada

Received	2018-07-23 02:01
Peer-Review Started	2018-07-23 06:22
To Make the First Decision	2018-08-27 02:28
Return for Revision	2018-08-28 02:07
Revised	2018-08-29 23:14
Second Decision	2018-09-04 08:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-05 23:14
Articles in Press	2018-10-05 23:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-09 05:53
Publish the Manuscript Online	2018-11-13 08:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Mode of delivery by an ulcerative colitis mother in a case of twins: Immunological differences in cord blood and placenta
Manuscript Source	Unsolicited Manuscript
All Author List	Garett Dunsmore, Petya Koleva, Reed Taylor Sutton, Lindsy Ambrosio, Vivian Huang and Shokrollah Elahi
ORCID	Author(s) ORCID Number Garett Dunsmore http://orcid.org/0000-0002-5170-9533 Petya Koleva http://orcid.org/0000-0001-6314-1773 Reed Taylor Sutton http://orcid.org/0000-0002-3009-1914 Lindsy Ambrosio http://orcid.org/0000-0003-2268-4629 Vivian Huang http://orcid.org/0000-0002-4524-9403 Shokrollah Elahi http://orcid.org/0000-0002-7215-2009
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institutes of Health Research Women and Children's Health Research Institute (WCHRI)
Corresponding Author	Shokrollah Elahi, MD, PhD, Associate Professor, School of Dentistry and Department of Medical Microbiology and Immunology, University of Alberta, 7020G Katz Group Centre, 11361-87th Ave NW, Edmonton T6G2E1, Alberta, Canada. elahi@ualberta.ca
Key Words	Caesarian section; Twins; Vaginal delivery; Immunophenotyping; CD71+ erythroid cells; Cord blood; Placental tissues
Core Tip	Mode of delivery may influence the immune system of offspring with possible long-term consequences. We report a case of twins one of which delivered vaginally while the other delivered by caesarian section (C-section). We found lower frequency of immune cells in the cord blood and placenta of C-section delivered compared to vaginally delivered newborn. However, higher percentage of neutrophils was observed in the placenta of C-section delivered newborn. Interestingly, for the very first time we found lower percentages of immunosuppressive CD71+ erythroid cells in both cord blood and placenta tissues of C-section delivered offspring. Thus, mode of delivery can modulate the immune system of newborn. In particular, lower frequency of CD71+ erythroid cells and its poten­tial impact on adaptation to microbiome merits further investigations.
Publish Date	2018-11-13 08:04
Citation	Dunsmore G, Koleva P, Sutton RT, Ambrosio L, Huang V, Elahi S. Mode of delivery by an ulcerative colitis mother in a case of twins: Immunological differences in cord blood and placenta. World J Gastroenterol 2018; 24(42): 4787-4797
URL	http://www.wjgnet.com/1007-9327/full/v24/i42/4787.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i42.4787

Full Article (PDF)	WJG-24-4787.pdf
Full Article (Word)	WJG-24-4787.doc
STROBE Statement	40991-STROBE statement.pdf
Manuscript File	40991-Review.docx
Answering Reviewers	40991-Answering reviewers.pdf
Audio Core Tip	40991-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	40991-Conflict-of-interest statement.pdf
Copyright License Agreement	40991-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	40991-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	40991-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	40991-Institutional review board statement.pdf
Peer-review Report	40991-Peer-review(s).pdf
Scientific Misconduct Check	40991-Scientific misconduct check.pdf
Scientific Editor Work List	40991-Scientific editor work list.pdf