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11/15/2018 1:34:32 PM | Browse: 143 | Download: 69
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 41370
Country of Manuscript Source South Korea
Received
2018-08-06 07:16
Peer-Review Started
2018-08-07 01:05
To Make the First Decision
2018-09-03 01:13
Return for Revision
2018-09-03 09:07
Revised
2018-09-07 08:30
Second Decision
2018-09-12 10:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-10 13:43
Articles in Press
2018-10-10 13:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-10-27 16:20
Typeset the Manuscript
2018-11-13 03:32
Publish the Manuscript Online
2018-11-15 13:34
ISSN 1948-5204 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript type Retrospective Study
Article Title Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Huapyong Kang, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song and Jeong Youp Park
ORCID
Author(s) ORCID Number
Huapyong Kang http://orcid.org/0000-0003-1790-0809
Jung Hyun Jo http://orcid.org/0000-0002-2641-8873
Hee Seung Lee http://orcid.org/0000-0002-2825-3160
Moon Jae Chung http://orcid.org/0000-0002-5920-8549
Seungmin Bang http://orcid.org/0000-0001-5209-8351
Seung Woo Park http://orcid.org/0000-0001-8230-964X
Si Young Song http://orcid.org/0000-0002-1417-4314
Jeong Youp Park http://orcid.org/0000-0003-0110-8606
Funding Agency and Grant Number
Correspondence To Jeong Youp Park, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1, Yonsei-Ro, Seodaemun-Gu, Seoul 03722, South Korea. sensass@yuhs.ac
Keywords Dose modification; Adverse event; Pancreatic cancer; Adenocarcinoma; FOLFIRINOX; Chemotherapy
Core Tip Although the efficacy of FOLFIRINOX for pancreatic cancer has been well demonstrated, its re­latively high toxicity rate is an important concern. We aimed to directly compare the efficacy and toxicity of standard-dose FOLFIRINOX and modified-dose FOLFIRINOX (mFOLFIRINOX, 75% of standard-dose) for pancreatic cancer. One hundred and thirty patients with pancreatic cancer (standard: 88 vs modified: 42) were reviewed retrospectively. Response rates, pro­gression-free survival, and overall survival were not dif­ferent between both groups. However, severe adverse events such as neutropenia, anorexia and diarrhea were significantly lower in the mFOLFIRINOX group. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy.
Publish Date 2018-11-15 13:34
Citation Kang H, Jo JH, Lee HS, Chung MJ, Bang S, Park SW, Song SY, Park JY. Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer. World J Gastrointest Oncol 2018; 10(11): 421-430
Url http://www.wjgnet.com/1948-5204/full/v10/i11/421.htm
DOI http://dx.doi.org/10.4251/wjgo.v10.i11.421
Full Article (PDF) WJGO-10-421.pdf
Full Article (Word) WJGO-10-421.doc
Manuscript File 41370-Review.docx
Answering Reviewers 41370-Answering reviewers.pdf
Audio Core Tip 41370-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41370-Conflict-of-interest statement.pdf
Copyright License Agreement 41370-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 41370-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41370-Language certificate.pdf
Peer-review Report 41370-Peer-review(s).pdf
Scientific Misconduct Check 41370-Scientific misconduct check.pdf
Scientific Editor Work List 41370-Scientific editor work list.pdf