Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	41454
Country	United States

Received	2018-08-09 02:44
Peer-Review Started	2018-08-09 09:30
To Make the First Decision	2018-10-22 00:38
Return for Revision	2018-10-22 02:50
Revised	2018-11-01 15:21
Second Decision	2018-11-23 10:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-27 03:34
Articles in Press	2018-11-27 03:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-18 02:25
Publish the Manuscript Online	2018-12-26 06:23

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Molecular therapeutic strategies targeting pancreatic cancer induced cachexia
Manuscript Source	Invited Manuscript
All Author List	Anastasiya Yakovenko, Miles Cameron and Jose Gilberto Trevino
ORCID	Author(s) ORCID Number Anastasiya Yakovenko http://orcid.org/0000-0001-6120-0135 Miles Cameron http://orcid.org/0000-0003-0996-3754 Jose Gilberto Trevino http://orcid.org/0000-0003-0616-368X
Funding Agency and Grant Number
Corresponding Author	Jose Gilberto Trevino, MD, Assistant Professor, Research Scientist, Surgeon, Surgical Oncologist, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, PO Box 100109, Gainesville, FL 32610, United States. jose.trevino@surgery.ufl.edu
Key Words	Cachexia; Muscle wasting; Pancreatic cancer; Cachexia therapies; Molecular signaling
Core Tip	Pancreatic cancer induced cachexia is a complex metabolic syndrome associated with increased morbidity, mortality and reduced quality of life. The complex pathophysiology of cachexia involves muscle wasting, systemic inflammation, and metabolic alterations. Molecular signaling pathways responsible for muscle wasting include TGF-β, myostatin/activin, IGF-1/PI3K/Akt, and JAK-STAT. IL-6, TNF-α, and INF-γ are the most well studied pro-cachectic cytokines that promote systemic inflammation. Metabolic alterations such as increased energy expenditure and glycolytic pathway dysfunction could be potentially improved with ketonemia, silibinin, and ω3-polyunsaturated fatty acids. Targeting molecular signaling pathways in pancreatic cancer induced cachexia could lead to discovery of effective therapies.
Publish Date	2018-12-26 06:23
Citation	Yakovenko A, Cameron M, Trevino JG. Molecular therapeutic strategies targeting pancreatic cancer induced cachexia. World J Gastrointest Surg 2018; 10(9): 95-106
URL	https://www.wjgnet.com/1948-9366/full/v10/i9/95.htm
DOI	https://dx.doi.org/10.4240/wjgs.v10.i9.95

Full Article (PDF)	WJGS-10-95.pdf
Full Article (Word)	WJGS-10-95.doc
Manuscript File	41454-Review.docx
Answering Reviewers	41454-Answering reviewers.pdf
Audio Core Tip	41454-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41454-Conflict-of-interest statement.pdf
Copyright License Agreement	41454-Copyright license agreement.pdf
Peer-review Report	41454-Peer-review(s).pdf
Scientific Misconduct Check	41454-Scientific misconduct check.pdf
Scientific Editor Work List	41454-Scientific editor work list.pdf