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12/26/2018 6:23:28 AM | Browse: 64 | Download: 30
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 41454
Country of Manuscript Source United States
Received
2018-08-09 02:44
Peer-Review Started
2018-08-09 09:30
To Make the First Decision
2018-10-22 00:38
Return for Revision
2018-10-22 02:50
Revised
2018-11-01 15:21
Second Decision
2018-11-23 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-27 03:34
Articles in Press
2018-11-27 03:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-12-18 02:25
Publish the Manuscript Online
2018-12-26 06:23
ISSN 1948-9366 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript type Minireviews
Article Title Molecular therapeutic strategies targeting pancreatic cancer induced cachexia
Manuscript Source Invited Manuscript
All Author List Anastasiya Yakovenko, Miles Cameron and Jose Gilberto Trevino
ORCID
Author(s) ORCID Number
Anastasiya Yakovenko http://orcid.org/0000-0001-6120-0135
Miles Cameron http://orcid.org/0000-0003-0996-3754
Jose Gilberto Trevino http://orcid.org/0000-0003-0616-368X
Funding Agency and Grant Number
Correspondence To Jose Gilberto Trevino, MD, Assistant Professor, Research Scientist, Surgeon, Surgical Oncologist, Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, PO Box 100109, Gainesville, FL32610, United States. jose.trevino@surgery.ufl.edu
Keywords Cachexia; Muscle wasting; Pancreatic cancer; Cachexia therapies; Molecular signaling
Core Tip Pancreatic cancer induced cachexia is a complex metabolic syndrome associated with increased morbidity, mortality and reduced quality of life. The complex pathophysiology of cachexia involves muscle wasting, systemic inflammation, and metabolic alterations. Molecular signaling pathways responsible for muscle wasting include TGF-β, myostatin/activin, IGF-1/PI3K/Akt, and JAK-STAT. IL-6, TNF-α, and INF-γ are the most well studied pro-cachectic cytokines that promote systemic inflammation. Metabolic alterations such as increased energy expenditure and glycolytic pathway dysfunction could be potentially improved with ketonemia, silibinin, and ω3-polyunsaturated fatty acids. Targeting molecular signaling pathways in pancreatic cancer induced cachexia could lead to discovery of effective therapies.
Publish Date 2018-12-26 06:23
Citation Yakovenko A, Cameron M, Trevino JG. Molecular therapeutic strategies targeting pancreatic cancer induced cachexia. World J Gastrointest Surg 2018; 10(9): 95-106
Url https://www.wjgnet.com/1948-9366/full/v10/i9/95.htm
DOI https://dx.doi.org/10.4240/wjgs.v10.i9.95
Full Article (PDF) WJGS-10-95.pdf
Full Article (Word) WJGS-10-95.doc
Manuscript File 41454-Review.docx
Answering Reviewers 41454-Answering reviewers.pdf
Audio Core Tip 41454-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 41454-Conflict-of-interest statement.pdf
Copyright License Agreement 41454-Copyright license agreement.pdf
Peer-review Report 41454-Peer-review(s).pdf
Scientific Misconduct Check 41454-Scientific misconduct check.pdf
Scientific Editor Work List 41454-Scientific editor work list.pdf